PPP1R8 - protein phosphatase 1 regulatory subunit 8 Gene

Homo sapiens

Also known as ARD1; ARD-1; NIPP1; NIPP-1; PRO2047

Gene ID: 5511 | Gene type: protein coding

About PPP1R8

Cytogenetic location: 1p35.3 Genomic coordinates (GRCh38): 1:27,830,782-27,851,676 (from NCBI)

This gene has 5 transcripts (splice variants), 242 orthologues and 2 paralogues. Ubiquitous expression in endometrium (RPKM 13.4), lymph node (RPKM 13.2) and 25 other tissues.

Summary

This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the Phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA. [provided by RefSeq, Jul 2008]

PPP1R8 Products(3)

mRNA	Protein	Name
NM_002713.4	NP_002704.1	nuclear inhibitor of protein phosphatase 1 isoform gamma
NM_014110.5	NP_054829.2	nuclear inhibitor of protein phosphatase 1 isoform alpha
NM_138558.3	NP_612568.1	nuclear inhibitor of protein phosphatase 1 isoform beta/delta

PPP1R8 Protein Structure

FHA

0
100
200
300
351 a.a.

Protein Preferred Names

Protein Names

nuclear inhibitor of protein phosphatase 1

RNase E

Related Diseases

Diseases

Alias

Xia-Gibbs Syndrome

Ahdc1-Related Intellectual Disability-Obstructive Sleep Apnea-Mild Dysmorphism Syndrome	XIGIS
Mrd25	Ahdc1-Related Intellectual Disability - Obstructive Sleep Apnea - Mild Dysmorphism Syndrome
Mental Retardation, Autosomal Dominant 25, Formerly	Mrd25, Formerly
Autosomal Dominant Mental Retardation 25	Autosomal Dominant Intellectual Disability 25
Xgs

Bubonic Plague

Black Death	Plague, Bubonic
Plague, Septicemic	Pestis Bubonica

Arthrogryposis, Distal, Type 1a

Distal Arthrogryposis Type 1	Digitotalar Dysmorphism
DA1A	Da1
Amcd1	Arthrogryposis, Distal, Type 2b4
Distal Arthrogryposis Type 1a	Arthrogryposis, Distal, Type 1
Arthrogryposis Multiplex Congenita Distal Type 1	Arthrogryposis Multiplex Congenita, Distal Type 1
Arthrogryposis Multiplex Congenita, Distal, Type I	Distal Arthrogryposis Type 1b
Arthrogryposis, Distal, 1a	Amc
Arthrogryposis Multiplex Congenita	Arthrogryposis, Distal, 2b4
DA2B4	Arthrogryposis Multiplex Congenita, Distal, Type 1
Arthrogryposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11004	PPP1R8 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PPP1R8	RGD	RGD:1306280
Mus musculus	PPP1R8	MGD	MGI:2140494
Felis catus	PPP1R8	VGNC	VGNC:69005
Bos taurus	PPP1R8	VGNC	VGNC:33249

Name
Email *

	Sorry, but the email address you supplied was invalid.