PPP1R8 - protein phosphatase 1 regulatory subunit 8 Gene

Also Known as ARD1; ARD-1; NIPP1; NIPP-1; PRO2047

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5511

About PPP1R8

Cytogenetic location: 1p35.3 Genomic coordinates (GRCh38): 1:27,830,782-27,851,676 (from NCBI)

This gene has 5 transcripts (splice variants), 242 orthologues and 2 paralogues. Ubiquitous expression in endometrium (RPKM 13.4), lymph node (RPKM 13.2) and 25 other tissues.

Summary

This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the Phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA. [provided by RefSeq, Jul 2008]

PPP1R8 Products (3)

mRNA Protein Name
NM_002713.4 NP_002704.1 nuclear inhibitor of protein phosphatase 1 isoform gamma
NM_014110.5 NP_054829.2 nuclear inhibitor of protein phosphatase 1 isoform alpha
NM_138558.3 NP_612568.1 nuclear inhibitor of protein phosphatase 1 isoform beta/delta

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables molecular function inhibitor activity EXP
EXP: Inferred from Experiment
22940584 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11739654 GOA
Cellular Component GO Annotation Evidence References Source
located in nuclear speck IDA
IDA: Inferred from direct assay
11739654 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP1R8 Protein Structure

FHA

FHA: FHA domain (49 - 118)

  • 0
  • 100
  • 200
  • 300
  • 351 a.a.
Protein Preferred Names Protein Names

nuclear inhibitor of protein phosphatase 1

  • RNase E

PPP1R8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PPP1R8 Q12972 PPP1CA Homo sapiens P62136
Y2H
22365833
Intra
PPP1R8 Q12972 PPP1CA Homo sapiens P62136
Anti Tag CoIP
18842582
Intra
PPP1R8 Q12972 PPP1CA Homo sapiens P62136
Anti Tag CoIP
33961781
Intra
PPP1R8 Q12972 APPBP2 Homo sapiens Q92624
Y2H Prey Pooling
25416956
Intra
PPP1R8 Q12972 APPBP2 Homo sapiens Q92624
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Xia-Gibbs Syndrome

  • Ahdc1-Related Intellectual Disability-Obstructive Sleep Apnea-Mild Dysmorphism Syndrome

  • XIGIS

  • Mrd25

  • Ahdc1-Related Intellectual Disability - Obstructive Sleep Apnea - Mild Dysmorphism Syndrome

  • Mental Retardation, Autosomal Dominant 25, Formerly

  • Mrd25, Formerly

  • Autosomal Dominant Mental Retardation 25

  • Autosomal Dominant Intellectual Disability 25

  • Xgs
Bubonic Plague

  • Black Death

  • Plague, Bubonic

  • Plague, Septicemic

  • Pestis Bubonica
Arthrogryposis, Distal, Type 1a

  • Distal Arthrogryposis Type 1

  • Digitotalar Dysmorphism

  • DA1A

  • Da1

  • Amcd1

  • Arthrogryposis, Distal, Type 2b4

  • Distal Arthrogryposis Type 1a

  • Arthrogryposis, Distal, Type 1

  • Arthrogryposis Multiplex Congenita Distal Type 1

  • Arthrogryposis Multiplex Congenita, Distal Type 1

  • Arthrogryposis Multiplex Congenita, Distal, Type I

  • Distal Arthrogryposis Type 1b

  • Arthrogryposis, Distal, 1a

  • Amc

  • Arthrogryposis Multiplex Congenita

  • Arthrogryposis, Distal, 2b4

  • DA2B4

  • Arthrogryposis Multiplex Congenita, Distal, Type 1

  • Arthrogryposis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11004 PPP1R8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PPP1R8 RGD RGD:1306280
Mus musculus PPP1R8 MGD MGI:2140494
Felis catus PPP1R8 VGNC VGNC:69005
Bos taurus PPP1R8 VGNC VGNC:33249
Others PPP1R8 NCBI