RPL10A - ribosomal protein L10a Gene

Also Known as L10A; CSA19; NEDD6; Csa-19

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4736

About RPL10A

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:35,468,401-35,470,780 (from NCBI)

This gene has 5 transcripts (splice variants), 160 orthologues and 3 paralogues. Ubiquitous expression in ovary (RPKM 957.8), bone marrow (RPKM 440.0) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L1P family of ribosomal proteins. It is located in the cytoplasm. The expression of this gene is downregulated in the thymus by cyclosporin-A (CsA), an immunosuppressive drug. Studies in mice have shown that the expression of the ribosomal protein L10a gene is downregulated in neural precursor cells during development. This gene previously was referred to as NEDD6 (neural precursor cell expressed, developmentally downregulated 6), but it has been renamed RPL10A (ribosomal protein 10a). As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPL10A Products (1)

mRNA Protein Name
NM_007104.5 NP_009035.3 60S ribosomal protein L10a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
24725412 GOA
enables structural constituent of ribosome IDA
IDA: Inferred from direct assay
23636399 GOA
Biological Process GO Annotation Evidence References Source
involved in cytoplasmic translation IDA
IDA: Inferred from direct assay
25957688 GOA
Cellular Component GO Annotation Evidence References Source
part of cytosolic large ribosomal subunit IDA
IDA: Inferred from direct assay
25957688 GOA
part of cytosolic large ribosomal subunit IPI
IPI: Inferred from physical interaction
25901680 GOA
located in cytosolic ribosome IDA
IDA: Inferred from direct assay
23636399 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPL10A Protein Structure

Ribosomal_L1

Ribosomal_L1: Ribosomal protein L1p/L10e family (22 - 212)

  • 0
  • 100
  • 200
  • 217 a.a.
Protein Preferred Names Protein Names

60S ribosomal protein L10a

  • NEDD-6

RPL10A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RPL10A P62906 RPS3A Homo sapiens P61247
Anti Tag CoIP
33961781
Intra
RPL10A P62906 RPL11 Homo sapiens P62913
Crosslink
30021884
Intra
RPL10A P62906 RGS17 Homo sapiens Q9UGC6
Validated Y2H
25416956
Intra
RPL10A P62906 RGS17 Homo sapiens Q9UGC6
Validated Y2H
32296183
Intra
RPL10A P62906 RGS17 Homo sapiens Q9UGC6
Y2H Array
32296183
Intra
RPL10A P62906 RGS17 Homo sapiens Q9UGC6
Y2H Prey Pooling
25416956
Intra
RPL10A P62906 RGS17 Homo sapiens Q9UGC6
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

RPL10A Antibodies

Cat. No. Product Name Application Reactivity
HY-P82135 RPL10A Antibody (YA1880) WB Human, Mouse, Rat
HY-P82135A RPL10A Antibody (YA1880)(PBS only) WB Human, Mouse, Rat

Related Diseases

Diseases Alias
Diamond-Blackfan Anemia

  • Congenital Pure Red Cell Aplasia

  • Aase Syndrome

  • Erythrogenesis Imperfecta

  • Anemia, Diamond-Blackfan

  • Congenital Hypoplastic Anemia

  • Aase-Smith Ii Syndrome

  • Bds

  • Blackfan-Diamond Anemia

  • Congenital Prca

  • Congenital Hypoplastic Anemia, Blackfan-Diamond Type

  • Dba

  • Blackfan - Diamond Syndrome

  • Chronic Constitutional Pure Red Cell Anaemia

  • Anemia Diamond Blackfan Type

  • Anemia Congenital Erythroid Hypoplastic

  • Aregenerative Anemia Chronic Congenital

  • Blackfan Diamond Syndrome

  • Red Cell Aplasia, Pure Hereditary

  • Aase-Smith Syndrome Ii

  • Bda

  • Blackfan Diamond Anemia

  • Blackfan-Diamond Disease

  • Blackfan-Diamond Syndrome

  • Chronic Congenital Agenerative Anemia

  • Congenital Erythroid Hypoplastic Anemia

  • Congenital Hypoplastic Anemia Of Blackfan And Diamond

  • Congenital Pure Red Cell Anemia

  • Hypoplastic Congenital Anemia

  • Inherited Erythroblastopenia

  • Pure Hereditary Red Cell Aplasia

  • Anemia, Hypoplastic, Congenital

  • Anemia Hypoplastic Congenital

  • Fanconi Anemia

  • Constitutional Aplastic Anemia

  • Diamond-Blackfan Anemia 1

  • Aase Smith Syndrome 2

  • Congenital Red Cell Aplasia

  • Red Cell Aplasia Of Infants

  • Pure Red Cell Aplasia Of Infants

  • Congenital Red Cell Aplastic Anaemia

  • Congenital Pure Red Cell Anaemia

  • Congenital Erythroid Hypoplasia

  • Pearson Marrow-Pancreas Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12161 RPL10A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RPL10A RGD RGD:620497
Macaca mulatta RPL10A VGNC VGNC:83460
Felis catus RPL10A VGNC VGNC:105242
Mus musculus RPL10A MGD MGI:1343877
Bos taurus RPL10A VGNC VGNC:54233
Canis familiaris RPL10A VGNC VGNC:105240
Others RPL10A NCBI