RPS3A - ribosomal protein S3A Gene

Also Known as S3A; FTE1; MFTL

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6189

About RPS3A

Cytogenetic location: 4q31.3 Genomic coordinates (GRCh38): 4:151,099,628-151,104,642 (from NCBI)

This gene has 14 transcripts (splice variants) and 186 orthologues. Ubiquitous expression in ovary (RPKM 854.6), bone marrow (RPKM 571.2) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S3AE family of ribosomal proteins. It is located in the cytoplasm. Disruption of the gene encoding rat ribosomal protein S3a, also named v-fos transformation effector protein, in v-fos-transformed rat cells results in reversion of the transformed phenotype. This gene is co-transcribed with the U73A and U73B small nucleolar RNA genes, which are located in its fourth and third introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]

RPS3A Products (2)

mRNA Protein Name
NM_001006.5 NP_000997.1 40S ribosomal protein S3a isoform 1
NM_001267699.2 NP_001254628.1 40S ribosomal protein S3a isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables mRNA 5'-UTR binding IDA
IDA: Inferred from direct assay
16213212 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11823430 GOA
enables structural constituent of ribosome IDA
IDA: Inferred from direct assay
23636399 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
9566973 GOA
involved in ribosomal small subunit biogenesis IDA
IDA: Inferred from direct assay
34516797 GOA
involved in translation IMP
IMP: Inferred from mutant phenotype
8877097 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11823430 GOA
located in cytosolic ribosome IDA
IDA: Inferred from direct assay
23636399 GOA
part of cytosolic small ribosomal subunit IDA
IDA: Inferred from direct assay
8706699 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
15572026 GOA
part of ribonucleoprotein complex IDA
IDA: Inferred from direct assay
17289661 GOA
part of small-subunit processome IDA
IDA: Inferred from direct assay
34516797 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPS3A Protein Structure

Ribosomal_S3Ae

Ribosomal_S3Ae: Ribosomal S3Ae family (13 - 222)

  • 0
  • 100
  • 200
  • 264 a.a.
Protein Preferred Names Protein Names

40S ribosomal protein S3a

  • fte-1

RPS3A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RPS3A P61247 HSP90AA1 Homo sapiens P07900
Y2H Pooling
16169070
Intra
RPS3A P61247 RPS14 Homo sapiens P62263
Crosslink
30021884
Intra
RPS3A P61247 RPL10A Homo sapiens P62906
Crosslink
30021884
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Diamond-Blackfan Anemia 6

  • DBA6

  • Aase-Smith Syndrome Ii

  • Aase Syndrome

  • Aase Smith Syndrome 2

  • Rpl5-Related Diamond-Blackfan Anemia

  • Anemia, Diamond-Blackfan, Type 6

  • Diamond-Blackfan Anemia 1
Encephalopathy, Familial, With Neuroserpin Inclusion Bodies

  • Familial Encephalopathy With Neuroserpin Inclusion Bodies

  • FENIB

  • Encephalopathy, Familial, With Collins Bodies

  • Familial Dementia With Neuroserpin Inclusion Bodies

  • Familial Encephalopathy With Collins Bodies
Tracheitis

  • Acute Tracheitis

  • Chronic Tracheitis

  • Bacterial Tracheitis

  • Acute Tracheitis Nos

  • Tracheitis Nos

  • Tracheal Inflammation
Diamond-Blackfan Anemia

  • Congenital Pure Red Cell Aplasia

  • Aase Syndrome

  • Erythrogenesis Imperfecta

  • Anemia, Diamond-Blackfan

  • Congenital Hypoplastic Anemia

  • Aase-Smith Ii Syndrome

  • Bds

  • Blackfan-Diamond Anemia

  • Congenital Prca

  • Congenital Hypoplastic Anemia, Blackfan-Diamond Type

  • Dba

  • Blackfan - Diamond Syndrome

  • Chronic Constitutional Pure Red Cell Anaemia

  • Anemia Diamond Blackfan Type

  • Anemia Congenital Erythroid Hypoplastic

  • Aregenerative Anemia Chronic Congenital

  • Blackfan Diamond Syndrome

  • Red Cell Aplasia, Pure Hereditary

  • Aase-Smith Syndrome Ii

  • Bda

  • Blackfan Diamond Anemia

  • Blackfan-Diamond Disease

  • Blackfan-Diamond Syndrome

  • Chronic Congenital Agenerative Anemia

  • Congenital Erythroid Hypoplastic Anemia

  • Congenital Hypoplastic Anemia Of Blackfan And Diamond

  • Congenital Pure Red Cell Anemia

  • Hypoplastic Congenital Anemia

  • Inherited Erythroblastopenia

  • Pure Hereditary Red Cell Aplasia

  • Anemia, Hypoplastic, Congenital

  • Anemia Hypoplastic Congenital

  • Fanconi Anemia

  • Constitutional Aplastic Anemia

  • Diamond-Blackfan Anemia 1

  • Aase Smith Syndrome 2

  • Congenital Red Cell Aplasia

  • Red Cell Aplasia Of Infants

  • Pure Red Cell Aplasia Of Infants

  • Congenital Red Cell Aplastic Anaemia

  • Congenital Pure Red Cell Anaemia

  • Congenital Erythroid Hypoplasia

  • Pearson Marrow-Pancreas Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12243 RPS3A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27558 Rps3a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus RPS3A VGNC VGNC:79996
Rattus norvegicus RPS3A RGD RGD:62078
Bos taurus RPS3A VGNC VGNC:55759
Mus musculus RPS3A MGD MGI:1202063
Others RPS3A NCBI