CC-3240
Based on 1 Customer Validation
CC-3240 (compound 13) is a molecular glue degrader of CaMKK2 based on CC-8977, with the IC50 of 9 nM.
For research use only. We do not sell to patients.
- Purity: 99.24%
- CAS No.: 2922675-91-8
- Formula: C52H64N6O7S
- Molecular Weight:917.17
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-427 | EC50 |
>8 μM
Compound: 13; CC-3240
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Antiproliferative activity against human A-427 cells assessed as reduction in cell growth incubated for 48 hrs by CellTiter assay
Antiproliferative activity against human A-427 cells assessed as reduction in cell growth incubated for 48 hrs by CellTiter assay
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[PMID: 38009718] |
Chemical Information
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CAS No. 2922675-91-8
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Appearance Solid
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Molecular Weight 917.17
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Formula C52H64N6O7S
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Color White to off-white
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SMILES
O=C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)[C@H](C(C)(C)C)NC(CCCCCCCCCOC4=CC5=C(C=C4)C(C6=CC(C7CCCC7)=C(C=C6)C(O)=O)=NC=N5)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (109.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (2.73 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0903 mL | 5.4516 mL | 10.9031 mL | 27.2578 mL |
| 5 mM | 0.2181 mL | 1.0903 mL | 2.1806 mL | 5.4516 mL | |
| 10 mM | 0.1090 mL | 0.5452 mL | 1.0903 mL | 2.7258 mL | |
| 15 mM | 0.0727 mL | 0.3634 mL | 0.7269 mL | 1.8172 mL | |
| 20 mM | 0.0545 mL | 0.2726 mL | 0.5452 mL | 1.3629 mL | |
| 25 mM | 0.0436 mL | 0.2181 mL | 0.4361 mL | 1.0903 mL | |
| 30 mM | 0.0363 mL | 0.1817 mL | 0.3634 mL | 0.9086 mL | |
| 40 mM | 0.0273 mL | 0.1363 mL | 0.2726 mL | 0.6814 mL | |
| 50 mM | 0.0218 mL | 0.1090 mL | 0.2181 mL | 0.5452 mL | |
| 60 mM | 0.0182 mL | 0.0909 mL | 0.1817 mL | 0.4543 mL | |
| 80 mM | 0.0136 mL | 0.0681 mL | 0.1363 mL | 0.3407 mL | |
| 100 mM | 0.0109 mL | 0.0545 mL | 0.1090 mL | 0.2726 mL |
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