2. Autophagy
  3. LRRK2
  4. IN04

IN04 is a inhibitor of leucine-rich repeat kinase 1 (LRRK1). IN04 can completely block the binding of ATP to the human LRRK1 kinase domain, thereby inhibiting the kinase activity of LRRK1. IN04 can significantly impair the bone resorption ability of osteoclasts, with an IC50 value of 5.72 μM. IN04 can be used for the study of osteoporosis.

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IN04

IN04 Chemical Structure

CAS No. : 838816-57-2

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Based on 1 publication(s) in Google Scholar

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Description

IN04 is a inhibitor of leucine-rich repeat kinase 1 (LRRK1). IN04 can completely block the binding of ATP to the human LRRK1 kinase domain, thereby inhibiting the kinase activity of LRRK1. IN04 can significantly impair the bone resorption ability of osteoclasts, with an IC50 value of 5.72 μM. IN04 can be used for the study of osteoporosis[1][2].

Molecular Weight

429.45

Formula

C20H19N3O6S
CAS No.
Appearance

Powder

Color

Light yellow to light brown

SMILES

O=C(OC)C1=CC=CC(NC(CSC2=NN=C(C3=CC(OC)=CC(OC)=C3)O2)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (58.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3286 mL 11.6428 mL 23.2856 mL
5 mM 0.4657 mL 2.3286 mL 4.6571 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3286 mL 11.6428 mL 23.2856 mL 58.2140 mL
5 mM 0.4657 mL 2.3286 mL 4.6571 mL 11.6428 mL
10 mM 0.2329 mL 1.1643 mL 2.3286 mL 5.8214 mL
15 mM 0.1552 mL 0.7762 mL 1.5524 mL 3.8809 mL
20 mM 0.1164 mL 0.5821 mL 1.1643 mL 2.9107 mL
25 mM 0.0931 mL 0.4657 mL 0.9314 mL 2.3286 mL
30 mM 0.0776 mL 0.3881 mL 0.7762 mL 1.9405 mL
40 mM 0.0582 mL 0.2911 mL 0.5821 mL 1.4553 mL
50 mM 0.0466 mL 0.2329 mL 0.4657 mL 1.1643 mL
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IN04 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IN04838816-57-2IN 04IN-04LRRK2Leucine-rich repeat kinase 2OsteoporosisLRRK1Inhibitorinhibitorinhibit

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