838816-57-2
Chemical Structure
IN04
- CAS No.: 838816-57-2
- Formula:C20H19N3O6S
- Molecular Weight:429.45
IUPAC Name: methyl 3-(2-((5-(3,5-dimethoxyphenyl)-1,3,4-oxadiazol-2-yl)thio)acetamido)benzoate
InChIKey: MCQJCSNFOKHYLJ-UHFFFAOYSA-N
SMILES: O=C(OC)C1=CC=CC(NC(CSC2=NN=C(C3=CC(OC)=CC(OC)=C3)O2)=O)=C1
Biological Activity: IN04 is a inhibitor of leucine-rich repeat kinase 1 (LRRK1). IN04 can completely block the binding of ATP to the human LRRK1 kinase domain, thereby inhibiting the kinase activity of LRRK1. IN04 can significantly impair the bone resorption ability of osteoclasts, with an IC50 value of 5.72 μM. IN04 can be used for the study of osteoporosis[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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IN04 | 98.51% | IN04 is a inhibitor of leucine-rich repeat kinase 1 (LRRK1). IN04 can completely block the binding of ATP to the human LRRK1 kinase domain, thereby inhibiting the kinase activity of LRRK1. IN04 can significantly impair the bone resorption ability of osteoclasts, with an IC50 value of 5.72 μM. IN04 can be used for the study of osteoporosis. | ||||||||||||||||||||
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- [1]. Chen Z, et al. Chemical IN04 Inhibits the Kinase Domain not the ROC Domain of LRRK1: Results from Homology Modeling and Molecular Docking. Med Chem. 2021;17(10):1140-1150. [Content Brief]
- [2]. Si M, et al. A small molecular inhibitor of LRRK1 identified by homology modeling and virtual screening suppresses osteoclast function, but not osteoclast differentiation, in vitro. Aging (Albany NY). 2019 May 21;11(10):3250-3261. [Content Brief]
Keywords
