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RPS23 - ribosomal protein S23 Gene

Also Known as S23; BTDD; uS12; MABAS; MCINS; PAMAS

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6228

About RPS23

Cytogenetic location: 5q14.2 Genomic coordinates (GRCh38): 5:82,273,320-82,278,354 (from NCBI)

This gene has 9 transcripts (splice variants), 182 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in ovary (RPKM 288.5), bone marrow (RPKM 141.7) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S12P family of ribosomal proteins. It is located in the cytoplasm. The protein shares significant amino acid similarity with S. cerevisiae ribosomal protein S28. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPS23 Products (1)

mRNA	Protein	Name
NM_001025.5	NP_001016.1	40S ribosomal protein S23

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20434207	GOA
enables structural constituent of ribosome	IDA IDA: Inferred from direct assay	23636399	GOA
enables structural constituent of ribosome	IMP IMP: Inferred from mutant phenotype	28257692	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cytoplasmic translation	IDA IDA: Inferred from direct assay	25957688	GOA
involved in maintenance of translational fidelity	IMP IMP: Inferred from mutant phenotype	28257692	GOA
involved in ribosomal small subunit biogenesis	IDA IDA: Inferred from direct assay	34516797	GOA
involved in stress granule assembly	IMP IMP: Inferred from mutant phenotype	28257692	GOA
involved in translation	IMP IMP: Inferred from mutant phenotype	28257692	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosolic ribosome	IDA IDA: Inferred from direct assay	23636399	GOA
part of cytosolic small ribosomal subunit	IDA IDA: Inferred from direct assay	8706699	GOA
part of small-subunit processome	IDA IDA: Inferred from direct assay	34516797	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPS23 Protein Structure

Ribosom_S12_S23

0
100
143 a.a.

Protein Preferred Names	Protein Names
40S ribosomal protein S23	homolog of yeast ribosomal protein S28

RPS23 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RPS23	P62266	DCC	Homo sapiens	P43146	Density Sedimentation	20434207
Intra	RPS23	P62266	OGFOD1	Homo sapiens	Q8N543	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Brachycephaly, Trichomegaly, And Developmental Delay	BTDD Macinnes Syndrome Mcins
Trichomegaly	Long Eyelashes TCMGLY Goldstein Hutt Syndrome Eyelashes, Long Movie Lashes
Myasthenic Syndrome, Congenital, 3a, Slow-Channel	Congenital Myasthenic Syndrome 3a CMS3A Congenital Myasthenic Syndrome 3a, Slow-Channel Myasthenic Syndrome, Congenital, Type 3a, Slow-Channel
Campylobacteriosis	Campylobacter Infections Campylobacter Infection Enteric Campylobacteriosis
Diamond-Blackfan Anemia	Congenital Pure Red Cell Aplasia Aase Syndrome Erythrogenesis Imperfecta Anemia, Diamond-Blackfan Congenital Hypoplastic Anemia Aase-Smith Ii Syndrome Bds Blackfan-Diamond Anemia Congenital Prca Congenital Hypoplastic Anemia, Blackfan-Diamond Type Dba Blackfan - Diamond Syndrome Chronic Constitutional Pure Red Cell Anaemia Anemia Diamond Blackfan Type Anemia Congenital Erythroid Hypoplastic Aregenerative Anemia Chronic Congenital Blackfan Diamond Syndrome Red Cell Aplasia, Pure Hereditary Aase-Smith Syndrome Ii Bda Blackfan Diamond Anemia Blackfan-Diamond Disease Blackfan-Diamond Syndrome Chronic Congenital Agenerative Anemia Congenital Erythroid Hypoplastic Anemia Congenital Hypoplastic Anemia Of Blackfan And Diamond Congenital Pure Red Cell Anemia Hypoplastic Congenital Anemia Inherited Erythroblastopenia Pure Hereditary Red Cell Aplasia Anemia, Hypoplastic, Congenital Anemia Hypoplastic Congenital Fanconi Anemia Constitutional Aplastic Anemia Diamond-Blackfan Anemia 1 Aase Smith Syndrome 2 Congenital Red Cell Aplasia Red Cell Aplasia Of Infants Pure Red Cell Aplasia Of Infants Congenital Red Cell Aplastic Anaemia Congenital Pure Red Cell Anaemia Congenital Erythroid Hypoplasia Pearson Marrow-Pancreas Syndrome
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12234	RPS23 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RPS23	VGNC	VGNC:53238
Mus musculus	RPS23	MGD	MGI:1913725
Rattus norvegicus	RPS23	RGD	RGD:621039
Others	RPS23	NCBI