OGFOD1 - 2-oxoglutarate and iron dependent oxygenase domain containing 1 Gene

Also Known as TPA1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55239

About OGFOD1

Cytogenetic location: 16q13 Genomic coordinates (GRCh38): 16:56,451,524-56,479,104 (from NCBI)

This gene has 11 transcripts (splice variants) and 205 orthologues. Ubiquitous expression in adrenal (RPKM 10.6), esophagus (RPKM 9.7) and 25 other tissues.

Summary

Enables peptidyl-proline 3-dioxygenase activity. Involved in several processes, including peptidyl-proline hydroxylation; regulation of translational termination; and stress granule assembly. Located in cytoplasmic stress granule; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

OGFOD1 Products (8)

mRNA Protein Name
NM_001324357.2 NP_001311286.1 prolyl 3-hydroxylase OGFOD1 isoform 2
NM_001324358.2 NP_001311287.1 prolyl 3-hydroxylase OGFOD1 isoform 3
NM_001324359.1 NP_001311288.1 prolyl 3-hydroxylase OGFOD1 isoform 4
NM_001324360.2 NP_001311289.1 prolyl 3-hydroxylase OGFOD1 isoform 4
NM_001324361.1 NP_001311290.1 prolyl 3-hydroxylase OGFOD1 isoform 3
NM_001324362.1 NP_001311291.1 prolyl 3-hydroxylase OGFOD1 isoform 5
NM_001324363.2 NP_001311292.1 prolyl 3-hydroxylase OGFOD1 isoform 6
NM_018233.4 NP_060703.3 prolyl 3-hydroxylase OGFOD1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables peptidyl-proline 3-dioxygenase activity EXP
EXP: Inferred from Experiment
24550447 GOA
enables peptidyl-proline 3-dioxygenase activity IDA
IDA: Inferred from direct assay
24550462 GOA
enables peptidyl-proline dioxygenase activity IDA
IDA: Inferred from direct assay
24550447 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in cell population proliferation IMP
IMP: Inferred from mutant phenotype
24550447 GOA
involved in peptidyl-proline hydroxylation IDA
IDA: Inferred from direct assay
24550447 GOA
involved in protein hydroxylation IDA
IDA: Inferred from direct assay
24550447 GOA
involved in regulation of translational termination IMP
IMP: Inferred from mutant phenotype
24550447 GOA
involved in stress granule assembly IMP
IMP: Inferred from mutant phenotype
24550447 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasmic stress granule IMP
IMP: Inferred from mutant phenotype
24550447 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OGFOD1 Protein Structure

2OG-FeII_Oxy_3

2OG-FeII_Oxy_3: 2OG-Fe(II) oxygenase superfamily (145 - 238)

Ofd1_CTDD

Ofd1_CTDD: Oxoglutarate and iron-dependent oxygenase degradation C-term (262 - 520)

  • 0
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  • 200
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  • 400
  • 500
  • 542 a.a.
Protein Preferred Names Protein Names

prolyl 3-hydroxylase OGFOD1

  • 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1

OGFOD1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
OGFOD1 Q8N543 FEM1A Homo sapiens Q9BSK4
Validated Y2H
32296183
Intra
OGFOD1 Q8N543 FEM1A Homo sapiens Q9BSK4
Y2H Array
32296183
Intra
OGFOD1 Q8N543 FEM1A Homo sapiens Q9BSK4
Y2H Prey Pooling
32296183
Intra
OGFOD1 Q8N543 RPS23 Homo sapiens P62266
Y2H Array
32296183
Intra
OGFOD1 Q8N543 RPS23 Homo sapiens P62266
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Intracranial Chondrosarcoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09760 OGFOD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus OGFOD1 RGD RGD:1308848
Macaca mulatta OGFOD1 VGNC VGNC:75459
Bos taurus OGFOD1 VGNC VGNC:32408
Mus musculus OGFOD1 MGD MGI:2442978
Felis catus OGFOD1 VGNC VGNC:63954
Canis familiaris OGFOD1 VGNC VGNC:44105
Others OGFOD1 NCBI