1. Autophagy
  2. LRRK2
  3. PFE-360

PFE-360 (Synonyms: PF-06685360)

Cat. No.: HY-120085
Handling Instructions

PFE-360 (PF-06685360) is a potent, selective, brain penetrated and orally active leucine-rich repeat kinase 2 (LRRK2) inhibitor with a mean IC50 of 2.3 nM in vivo.

For research use only. We do not sell to patients.

PFE-360 Chemical Structure

PFE-360 Chemical Structure

CAS No. : 1527475-61-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 385 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2650 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
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Description

PFE-360 (PF-06685360) is a potent, selective, brain penetrated and orally active leucine-rich repeat kinase 2 (LRRK2) inhibitor with a mean IC50 of 2.3 nM in vivo[1][2].

IC50 & Target

IC50: 2.3 nM (LRRK2 in vivo) [1][2].

Molecular Weight

308.34

Formula

C₁₆H₁₆N₆O

CAS No.

1527475-61-1

SMILES

N#CC1=CC(C2=CNC3=NC=NC(N4CCOCC4)=C32)=CN1C

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10.42 mg/mL (33.79 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2432 mL 16.2159 mL 32.4317 mL
5 mM 0.6486 mL 3.2432 mL 6.4863 mL
10 mM 0.3243 mL 1.6216 mL 3.2432 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.04 mg/mL (3.37 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.04 mg/mL (3.37 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.04 mg/mL (3.37 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
PFE-360
Cat. No.:
HY-120085
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