1527475-61-1
1527475-61-1
Chemical Structure
PFE-360
Synonym(s): PF-06685360
- CAS No.: 1527475-61-1
- Formula:C16H16N6O
- Molecular Weight:308.34
IUPAC Name: 1-methyl-4-(4-morpholino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-1H-pyrrole-2-carbonitrile
InChIKey: IYQTYHISVSPMSU-UHFFFAOYSA-N
SMILES: N#CC1=CC(C2=CNC3=NC=NC(N4CCOCC4)=C32)=CN1C
Biological Activity: PFE-360 (PF-06685360) is a potent, selective, brain penetrated and orally active leucine-rich repeat kinase 2 (LRRK2) inhibitor with a mean IC50 of 2.3 nM in vivo[1][2].
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PFE-360 | 99.10% | PFE-360 (PF-06685360) is a potent, selective, brain penetrated and orally active leucine-rich repeat kinase 2 (LRRK2) inhibitor with a mean IC50 of 2.3 nM in vivo. | ||||||||||||||||||||
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References
- [1]. Marco A.S. Baptista, et al. LRRK2 Kinase Inhibitors of Different Structural Classes Induce Abnormal Accumulation of Lamellar Bodies in Type II Pneumocytes in Non-Human Primates but are Reversible and Without Pulmonary Functional Consequences.
- [2]. Andersen MA, et al. Parkinson's disease-like burst firing activity in subthalamic nucleus induced by AAV-α-synuclein is normalized by LRRK2 modulation. Neurobiol Dis. 2018 Aug;116:13-27. [Content Brief]
Keywords
