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  2. LRRK2
  3. CZC-54252 hydrochloride

CZC-54252 hydrochloride 

Cat. No.: HY-B0792A
Handling Instructions

CZC-54252 hydrochloride is a potent and selective LRRK2 inhibitor with IC50s of 1.28 nM and 1.85 nM for wild-type and G2019S LRRK2, respectively. G2019S LRRK2-induced human neuronal injury is attenuated by CZC-54252 hydrochloride with an EC50 of ~1 nM.CZC-54252 hydrochloride has a neuroprotective activity.

For research use only. We do not sell to patients.

CZC-54252 hydrochloride Chemical Structure

CZC-54252 hydrochloride Chemical Structure

CAS No. : 1784253-05-9

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Description

CZC-54252 hydrochloride is a potent and selective LRRK2 inhibitor with IC50s of 1.28 nM and 1.85 nM for wild-type and G2019S LRRK2, respectively. G2019S LRRK2-induced human neuronal injury is attenuated by CZC-54252 hydrochloride with an EC50 of ~1 nM.CZC-54252 hydrochloride has a neuroprotective activity[1].

IC50 & Target

IC50: 1.28 nM (Wild-type LRRK2) and 1.85 nM (G2019S LRRK2)[1]

Molecular Weight

541.45

Formula

C₂₂H₂₆Cl₂N₆O₄S

CAS No.

1784253-05-9

SMILES

CS(=O)(NC1=CC=CC=C1NC2=NC(NC3=CC=C(N4CCOCC4)C=C3OC)=NC=C2Cl)=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

CZC-54252CZC54252CZC 54252LRRK2Leucine-rich repeat kinase 2neuroprotectiveneuronalinjuryLRRK2-G2019SInhibitorinhibitorinhibit

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CZC-54252 hydrochloride
Cat. No.:
HY-B0792A
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