CZC-54252 hydrochloride
Based on 1 Customer Validation
CZC-54252 hydrochloride is a potent and selective LRRK2 inhibitor with IC50s of 1.28 nM and 1.85 nM for wild-type and G2019S LRRK2, respectively. G2019S LRRK2-induced human neuronal injury is attenuated by CZC-54252 hydrochloride with an EC50 of ~1 nM.CZC-54252 hydrochloride has a neuroprotective activity.
For research use only. We do not sell to patients.
- Purity: 98.44%
- CAS No.: 1784253-05-9
- Formula: C22H26Cl2N6O4S
- Molecular Weight:541.45
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
IC50: 1.28 nM (Wild-type LRRK2) and 1.85 nM (G2019S LRRK2)[1]
Chemical Information
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CAS No. 1784253-05-9
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Appearance Solid
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Molecular Weight 541.45
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Formula C22H26Cl2N6O4S
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Color Light yellow to orange
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SMILES
CS(=O)(NC1=CC=CC=C1NC2=NC(NC3=CC=C(N4CCOCC4)C=C3OC)=NC=C2Cl)=O.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 33.33 mg/mL (61.56 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8469 mL | 9.2345 mL | 18.4689 mL | 46.1723 mL |
| 5 mM | 0.3694 mL | 1.8469 mL | 3.6938 mL | 9.2345 mL | |
| 10 mM | 0.1847 mL | 0.9234 mL | 1.8469 mL | 4.6172 mL | |
| 15 mM | 0.1231 mL | 0.6156 mL | 1.2313 mL | 3.0782 mL | |
| 20 mM | 0.0923 mL | 0.4617 mL | 0.9234 mL | 2.3086 mL | |
| 25 mM | 0.0739 mL | 0.3694 mL | 0.7388 mL | 1.8469 mL | |
| 30 mM | 0.0616 mL | 0.3078 mL | 0.6156 mL | 1.5391 mL | |
| 40 mM | 0.0462 mL | 0.2309 mL | 0.4617 mL | 1.1543 mL | |
| 50 mM | 0.0369 mL | 0.1847 mL | 0.3694 mL | 0.9234 mL | |
| 60 mM | 0.0308 mL | 0.1539 mL | 0.3078 mL | 0.7695 mL |
CZC-54252 hydrochloride Related Classifications
HY-B0792A Related Classifications
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