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Cat. No.: HY-182928

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LRRK2-IN-21

LRRK2-IN-21 is a selective, blood-brain barrier-permeable LRRK2 kinase inhibitor with an IC₅₀ of 0.35 nM. LRRK2-IN-21 inhibits TTK kinase with an IC₅₀ of 70 nM. LRRK2-IN-21 is applicable to the research of Parkinson's disease.

For research use only. We do not sell to patients.

CAS No.: 3018825-60-7
Formula: C₁₇H₁₉F₃N₆O₂
Molecular Weight:396.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

LRRK2-IN-21 Chemical Structure

CAS No.: 3018825-60-7

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Parmacokinetics
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

In Vitro

LRRK2-IN-21 (Compound 12) inhibits LRRK2 Ser935 dephosphorylation in unbound primary human PBMCs with an IC₅₀ of 40 nM^[1].
LRRK2-IN-21 exhibits high metabolic stability in rat, dog, and human hepatocytes with intrinsic clearance values of 26, <14, and <6 mL/min/kg respectively^[1].
LRRK2-IN-21 inhibits hERG channels with an IC₅₀ of 30 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	CL_plasma	CL_hepatic	MRT	Bioavailability
Rat^[1]	1 mg/kg	i.v.	7.5 mL/min/kg	22 mL/min/kg	7.9 h	/
Rat^[1]	5 mg/kg	p.o.	/	/	/	67 %

Chemical Information

CAS No. 3018825-60-7
Molecular Weight 396.37
Formula C₁₇H₁₉F₃N₆O₂
SMILES

CC1=NN(C(N2)=C1OC[C@@H]3COC[C@H]3NC4=NC2=NC=C4C(F)(F)F)C5CC5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yu EC, et al. Discovery of Potent, Selective, CNS-Penetrant Macrocyclic LRRK2 Inhibitors for the Treatment of Parkinson's Disease. J Med Chem. 2026;69(7):8548-8560. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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