2. Autophagy Cytoskeleton Cell Cycle/DNA Damage
  3. LRRK2 Mps1
  4. LRRK2-IN-21

LRRK2-IN-21 is a selective, blood-brain barrier-permeable LRRK2 kinase inhibitor with an IC50 of 0.35 nM. LRRK2-IN-21 inhibits TTK kinase with an IC50 of 70 nM. LRRK2-IN-21 is applicable to the research of Parkinson's disease.

For research use only. We do not sell to patients.

LRRK2-IN-21

LRRK2-IN-21 Chemical Structure

CAS No. : 3018825-60-7

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LRRK2-IN-21 Related Antibodies

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Description

LRRK2-IN-21 is a selective, blood-brain barrier-permeable LRRK2 kinase inhibitor with an IC50 of 0.35 nM. LRRK2-IN-21 inhibits TTK kinase with an IC50 of 70 nM. LRRK2-IN-21 is applicable to the research of Parkinson's disease[1].

In Vitro

LRRK2-IN-21 (Compound 12) inhibits LRRK2 Ser935 dephosphorylation in unbound primary human PBMCs with an IC50 of 40 nM[1].
LRRK2-IN-21 exhibits high metabolic stability in rat, dog, and human hepatocytes with intrinsic clearance values of 26, <14, and <6 mL/min/kg respectively[1].
LRRK2-IN-21 inhibits hERG channels with an IC50 of 30 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LRRK2-IN-21 Related Antibodies
Parmacokinetics
Species Dose Route CLplasma CLhepatic MRT Bioavailability
Rat[1] 1 mg/kg i.v. 7.5 mL/min/kg 22 mL/min/kg 7.9 h /
Rat[1] 5 mg/kg p.o. / / / 67 %
Molecular Weight

396.37

Formula

C17H19F3N6O2
CAS No.
SMILES

CC1=NN(C(N2)=C1OC[C@@H]3COC[C@H]3NC4=NC2=NC=C4C(F)(F)F)C5CC5
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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LRRK2-IN-21 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LRRK2-IN-213018825-60-7LRRK2Mps1Leucine-rich repeat kinase 2Monopolar spindle 1primary human PBMCsrat modelsrat hepatocytesdog hepatocytespregnane X receptorhuman hepatocyteshERG channelsG2019S LRRK2 kinaseLRRK2 kinaseparkinson’s diseaseInhibitorinhibitorinhibit

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