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Cat. No.: HY-P10636

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Nictide

Nictide is a peptide substrate of LRRK2 (leucine-rich repeat protein kinase-2). Nictide can be phosphorylated by the activated LRRK2[G2019S] with a Km of 10 μM.

For research use only. We do not sell to patients.

CAS No.: 1159973-22-4
Formula: C₁₂₃H₁₉₃N₄₅O₂₈
Molecular Weight:2750.13

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Nictide Chemical Structure

CAS No.: 1159973-22-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Nictide is a peptide substrate of LRRK2 (leucine-rich repeat protein kinase-2). Nictide can be phosphorylated by the activated LRRK2[G2019S] with a Km of 10 μM^[1].

Chemical Information

CAS No. 1159973-22-4
Molecular Weight 2750.13
Formula C₁₂₃H₁₉₃N₄₅O₂₈
Sequence

Arg-Leu-Gly-Trp-Trp-Arg-Phe-Tyr-Thr-Leu-Arg-Arg-Ala-Arg-Gln-Gly-Asn-Thr-Lys-Gln-Arg
Sequence Shortening

RLGWWRFYTLRRARQGNTKQR
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (257 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. R. Jeremy Nichols, et al. Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson’s disease. Biochem J. 2009 Oct 23; 424(1): 47–60. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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