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RGS2 - regulator of G protein signaling 2 Gene

Also Known as G0S8

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5997

About RGS2

Cytogenetic location: 1q31.2 Genomic coordinates (GRCh38): 1:192,809,039-192,812,275 (from NCBI)

This gene has 4 transcripts (splice variants), 242 orthologues and 23 paralogues. Broad expression in bone marrow (RPKM 211.2), adrenal (RPKM 208.4) and 20 other tissues.

Summary

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis. [provided by RefSeq, Aug 2009]

RGS2 Products (1)

mRNA	Protein	Name
NM_002923.4	NP_002914.1	regulator of G-protein signaling 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables G-protein alpha-subunit binding	IPI IPI: Inferred from physical interaction	19478087	GOA
enables GTPase activator activity	IMP IMP: Inferred from mutant phenotype	19478087	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14608379	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11278586	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10791963	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	11278586	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RGS2 Protein Structure

RGS

0
100
200
211 a.a.

Protein Preferred Names	Protein Names
regulator of G-protein signaling 2	G0 to G1 switch regulatory 8, 24kD

RGS2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RGS2	P41220	MTUS2	Homo sapiens	Q5JR59-3	Y2H Bait-Prey Pool	25910212
Intra	RGS2	P41220	MTUS2	Homo sapiens	Q5JR59-3	Validated Y2H	25910212
Intra	RGS2	P41220	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	25910212
Intra	RGS2	P41220	PPP1R9A	Homo sapiens	Q9ULJ8	Pull Down	17464283
Intra	RGS2	P41220	LRRK2	Homo sapiens	Q5S007	Confocal	24794857
Intra	RGS2	P41220	MTUS2	Homo sapiens	Q5JR59	Y2H Prey Pooling	25416956
Intra	RGS2	P41220	MTUS2	Homo sapiens	Q5JR59	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Panic Disorder	Panic Anxiety Syndrome Panic Panic Disorder 1 Episodic Paroxysmal Anxiety Disorder
Anxiety	Anxiety Disorder Anxiety Disorders Anxiety State Anxieties Anxiety Neurosis
Agoraphobia	Fear Of Open Spaces Phobia Of Going Out
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-169282	RGS2–Galpha-q PPI-IN-1	Agonist	/	Unkown
HY-N20711	Usenamine A		/	Unkown
HY-RS11916	RGS2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18970	Rgs2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25460	Rgs2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RGS2	VGNC	VGNC:45529
Macaca mulatta	RGS2	VGNC	VGNC:106484
Mus musculus	RGS2	MGD	MGI:1098271
Rattus norvegicus	RGS2	RGD	RGD:621665
Felis catus	RGS2	VGNC	VGNC:69314
Others	RGS2	NCBI