PPP1R9A - protein phosphatase 1 regulatory subunit 9A Gene

Homo sapiens

Also known as NRB1; NRBI; Neurabin-I

Gene ID: 55607 | Gene type: protein coding

About PPP1R9A

Cytogenetic location: 7q21.3 Genomic coordinates (GRCh38): 7:94,907,236-95,296,415 (from NCBI)

This gene has 8 transcripts (splice variants), 214 orthologues and 2 paralogues. Broad expression in brain (RPKM 4.9), adrenal (RPKM 2.5) and 21 other tissues.

Summary

This gene is imprinted, and located in a cluster of imprinted genes on chromosome 7q12. This gene is transcribed in both neuronal and multiple embryonic tissues, and it is maternally expressed mainly in embryonic skeletal muscle tissues and biallelically expressed in other embryonic tissues. The protein encoded by this gene includes a PDZ domain and a sterile alpha motif (SAM). It is a regulatory subunit of protein Phosphatase I, and controls actin Cytoskeleton reorganization. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

PPP1R9A Products(5)

mRNA	Protein	Name
NM_001166160.2	NP_001159632.1	neurabin-1 isoform 1
NM_001166161.1	NP_001159633.1	neurabin-1 isoform 2
NM_001166162.1	NP_001159634.1	neurabin-1 isoform 3
NM_001166163.1	NP_001159635.1	neurabin-1 isoform 5
NM_017650.3	NP_060120.2	neurabin-1 isoform 4

PPP1R9A Protein Structure

PDZ

SAM_2

0
200
400
600
800
1000
1098 a.a.

Protein Preferred Names

Protein Names

neurabin-1

neural tissue-specific F-actin-binding protein I

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11005	PPP1R9A Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PPP1R9A	VGNC	VGNC:44902
Felis catus	PPP1R9A	VGNC	VGNC:64326
Mus musculus	PPP1R9A	MGD	MGI:2442401
Macaca mulatta	PPP1R9A	VGNC	VGNC:76258
Rattus norvegicus	PPP1R9A	RGD	RGD:632280
Bos taurus	PPP1R9A	VGNC	VGNC:33250

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