2. Autophagy
  3. LRRK2
  4. LRRKtide

LRRKtide is a polypeptide substrate. LRRKtide is a specific phosphorylation substrate of LRRK2, a kinase associated with Parkinson's disease, and its phosphorylation site is a threonine residue. LRRKtide can be used for characterization of the catalytic properties of LRRK2, as well as studies on kinase activity and inhibition. LRRKtide is applicable to research related to Parkinson's disease.

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Custom Peptide Synthesis

LRRKtide

LRRKtide Chemical Structure

CAS No. : 1071466-49-3

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Based on 1 publication(s) in Google Scholar

LRRKtide Related Antibodies

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  • Purity & Documentation

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Description

LRRKtide is a polypeptide substrate. LRRKtide is a specific phosphorylation substrate of LRRK2, a kinase associated with Parkinson's disease, and its phosphorylation site is a threonine residue. LRRKtide can be used for characterization of the catalytic properties of LRRK2, as well as studies on kinase activity and inhibition. LRRKtide is applicable to research related to Parkinson's disease[1][2].

In Vitro

LRRKtide is a key tool peptide for dissecting the functions of LRRK2 and the mechanisms of Parkinson's disease[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LRRKtide Related Antibodies
Molecular Weight

1931.25

Formula

C83H147N31O22
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Arg-Leu-Gly-Arg-Asp-Lys-Tyr-Lys-Thr-Leu-Arg-Gln-Ile-Arg-Gln
Sequence Shortening

RLGRDKYKTLRQIRQ
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (51.78 mM)

DMSO : 20 mg/mL (10.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5178 mL 2.5890 mL 5.1780 mL
5 mM 0.1036 mL 0.5178 mL 1.0356 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 0.5178 mL 2.5890 mL 5.1780 mL 12.9450 mL
5 mM 0.1036 mL 0.5178 mL 1.0356 mL 2.5890 mL
10 mM 0.0518 mL 0.2589 mL 0.5178 mL 1.2945 mL
H2O 15 mM 0.0345 mL 0.1726 mL 0.3452 mL 0.8630 mL
20 mM 0.0259 mL 0.1294 mL 0.2589 mL 0.6472 mL
25 mM 0.0207 mL 0.1036 mL 0.2071 mL 0.5178 mL
30 mM 0.0173 mL 0.0863 mL 0.1726 mL 0.4315 mL
40 mM 0.0129 mL 0.0647 mL 0.1294 mL 0.3236 mL
50 mM 0.0104 mL 0.0518 mL 0.1036 mL 0.2589 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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LRRKtide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LRRKtide1071466-49-3LRRK2Leucine-rich repeat kinase 2I2020T mutant leucine-rich repeat kinase2BAC-transgenic mouse brainGDPleucine-rich repeat kinase2 (LRRK2)ADPLRRKtideAGMPparkinson’s diseasemoesinGTPInhibitorinhibitorinhibit

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