1071466-49-3
Chemical Structure
LRRKtide
- CAS 番号: 1071466-49-3
- Formula:C83H147N31O22
- Molecular Weight:1931.25
InChIKey: MBUGSPDELVYCJP-JVMUIATRSA-N
SMILES: OC(C=C1)=CC=C1C[C@@H](C(N[C@@H](CCCCN)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(O)=O)CCC(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC([C@H](CCCCN)NC([C@H](CC(O)=O)NC([C@H](CCCNC(N)=N)NC(CNC([C@H](CC(C)C)NC([C@@H](N)CCCNC(N)=N)=O)=O)=O)=O)=O)=O
Biological Activity: LRRKtide is a polypeptide substrate. LRRKtide is a specific phosphorylation substrate of LRRK2, a kinase associated with Parkinson's disease, and its phosphorylation site is a threonine residue. LRRKtide can be used for characterization of the catalytic properties of LRRK2, as well as studies on kinase activity and inhibition. LRRKtide is applicable to research related to Parkinson's disease[1][2].
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LRRKtide | 99.94% | LRRKtide is a polypeptide substrate. LRRKtide is a specific phosphorylation substrate of LRRK2, a kinase associated with Parkinson's disease, and its phosphorylation site is a threonine residue. LRRKtide can be used for characterization of the catalytic properties of LRRK2, as well as studies on kinase activity and inhibition. LRRKtide is applicable to research related to Parkinson's disease. | ||||||||||||||||||||
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- [1]. Liu M, et al. Kinetic mechanistic studies of wild-type leucine-rich repeat kinase 2: characterization of the kinase and GTPase activities. Biochemistry. 2010;49(9):2008-2017. [Content Brief]
- [2]. Ray S, et al. The Parkinson disease-linked LRRK2 protein mutation I2020T stabilizes an active state conformation leading to increased kinase activity. J Biol Chem. 2014;289(19):13042-13053. [Content Brief]
Keywords
