TCF25 - transcription factor 25 Gene

Also Known as Hulp1; NULP1; FKSG26; PRO2620; hKIAA1049

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 22980

About TCF25

Cytogenetic location: 16q24.3 Genomic coordinates (GRCh38): 16:89,873,592-89,911,379 (from NCBI)

This gene has 26 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in thyroid (RPKM 33.1), testis (RPKM 28.8) and 25 other tissues.

Summary

TCF25 is a member of the basic helix-loop-helix (bHLH) family of transcription factors that are important in embryonic development (Steen and Lindholm, 2008 [PubMed 18068114]).[supplied by OMIM, Sep 2008]

TCF25 Products (1)

mRNA Protein Name
NM_014972.3 NP_055787.1 transcription factor 25

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
16574069 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16574069 GOA
involved in regulation of protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
30244831 GOA
involved in rescue of stalled ribosome IDA
IDA: Inferred from direct assay
30244831 GOA
Cellular Component GO Annotation Evidence References Source
part of RQC complex IDA
IDA: Inferred from direct assay
30244831 GOA
is active in nucleus IDA
IDA: Inferred from direct assay
16574069 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TCF25 Protein Structure

Tcf25

Tcf25: Transcriptional repressor TCF25 (247 - 588)

  • 0
  • 200
  • 400
  • 600
  • 676 a.a.
Protein Preferred Names Protein Names

transcription factor 25

  • TCF-25

TCF25 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TCF25 Q9BQ70 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
Intra
TCF25 Q9BQ70 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
Intra
TCF25 Q9BQ70 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
Intra
TCF25 Q9BQ70 GPRASP2 Homo sapiens Q96D09
Y2H Prey Pooling
32296183
Intra
TCF25 Q9BQ70 GPRASP2 Homo sapiens Q96D09
Y2H Array
32296183
Intra
TCF25 Q9BQ70 GPRASP2 Homo sapiens Q96D09
Anti Tag CoIP
33961781
Intra
TCF25 Q9BQ70 GPRASP2 Homo sapiens Q96D09
Anti Tag CoIP
28514442
Intra
TCF25 Q9BQ70 GPRASP2 Homo sapiens Q96D09
Anti Tag CoIP
35271311
Intra
TCF25 Q9BQ70 GPRASP2 Homo sapiens Q96D09
Y2H Prey Pooling
25416956
Intra
TCF25 Q9BQ70 LRRK2 Homo sapiens Q5S007
Protein Array
24947832
Intra
TCF25 Q9BQ70 SAT1 Homo sapiens P21673
Y2H
21516116
Intra
TCF25 Q9BQ70 SAT1 Homo sapiens P21673
Y2H Array
25416956
Intra
TCF25 Q9BQ70 SAT1 Homo sapiens P21673
Y2H Pooling
19060904
Intra
TCF25 Q9BQ70 SAT1 Homo sapiens P21673
Y2H Array
32296183
Intra
TCF25 Q9BQ70 SAT1 Homo sapiens P21673
Y2H Prey Pooling
32296183
Intra
TCF25 Q9BQ70 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
TCF25 Q9BQ70 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
TCF25 Q9BQ70 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
TCF25 Q9BQ70 MAGEA11 Homo sapiens P43364
Y2H Prey Pooling
32296183
Intra
TCF25 Q9BQ70 MAGEA11 Homo sapiens P43364
Y2H Array
32296183
Intra
TCF25 Q9BQ70 APPBP2 Homo sapiens Q92624
Y2H Prey Pooling
25416956
Intra
TCF25 Q9BQ70 APPBP2 Homo sapiens Q92624
Y2H Array
25416956
Intra
TCF25 Q9BQ70 KASH5 Homo sapiens Q8N6L0
Validated Y2H
25416956
Intra
TCF25 Q9BQ70 KASH5 Homo sapiens Q8N6L0
Y2H Array
25416956
Intra
TCF25 Q9BQ70 GPX7 Homo sapiens Q96SL4
Y2H Prey Pooling
32296183
Intra
TCF25 Q9BQ70 GPX7 Homo sapiens Q96SL4
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations

  • Star Syndrome

  • Syndactyly-Telecanthus-Anogenital And Renal Malformations Syndrome

  • Syndactyly With Renal And Anogenital Malformations

  • STAR

  • Syndactyly, Telecanthus, Anogenital And Renal Malformations

  • Toe Syndactyly, Telecanthus, Anogenital And Renal Malformations
Vulvovaginitis

  • Vulvo-Vaginitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14305 TCF25 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TCF25 VGNC VGNC:66025
Mus musculus TCF25 MGD MGI:1914105
Macaca mulatta TCF25 VGNC VGNC:99607
Bos taurus TCF25 VGNC VGNC:35692
Canis familiaris TCF25 VGNC VGNC:47196
Rattus norvegicus TCF25 RGD RGD:1309054
Others TCF25 NCBI