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Cat. No.: HY-155153

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CDK9-IN-24

CDK9-IN-24 (compound 21a) is a highly selective CDK9 inhibitor with significant inhibitory effect on tumor growth. CDK9-IN-24 effectively blocks cell proliferation and induces apoptosis by downregulating Mcl-1 and c-Myc, and can be used in acute myeloid leukemia research.

For research use only. We do not sell to patients.

CAS No.: 3052935-72-2
Formula: C₂₇H₃₁N₃O₄
Molecular Weight:461.55

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

CDK9-IN-24 Chemical Structure

CAS No.: 3052935-72-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

CDK9

All CDK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.7 μM Compound: 21a	Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 72 hrs Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 72 hrs	[PMID: 37572539]
BT-549	IC₅₀	0.21 μM Compound: 21a	Antiproliferative activity against human BT-549 cells assessed as reduction in cell viability measured after 72 hrs Antiproliferative activity against human BT-549 cells assessed as reduction in cell viability measured after 72 hrs	[PMID: 37572539]
CWR22R	IC₅₀	1.25 μM Compound: LWT-111	Antiproliferative activity against human 22Rv1 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay Antiproliferative activity against human 22Rv1 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay	[PMID: 37672930]
HCT-116	IC₅₀	0.02 μM Compound: 21a	Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability measured after 72 hrs Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability measured after 72 hrs	[PMID: 37572539]
HEK293	IC₅₀	10.7 μM Compound: 21a	Cytotoxicity against human HEK293 cells assessed as reduction in cell viability measured after 72 hrs Cytotoxicity against human HEK293 cells assessed as reduction in cell viability measured after 72 hrs	[PMID: 37572539]
HepG2	IC₅₀	0.41 μM Compound: 21a	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability measured after 72 hrs Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability measured after 72 hrs	[PMID: 37572539]
HL-60	IC₅₀	0.18 μM Compound: 21a	Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability measured after 72 hrs Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability measured after 72 hrs	[PMID: 37572539]
HT-29	IC₅₀	1.06 μM Compound: 21a	Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability measured after 72 hrs Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability measured after 72 hrs	[PMID: 37572539]
L02	IC₅₀	10.6 μM Compound: 21a	Cytotoxicity against human L02 cells assessed as reduction in cell viability measured after 72 hrs Cytotoxicity against human L02 cells assessed as reduction in cell viability measured after 72 hrs	[PMID: 37572539]
MCF7	IC₅₀	0.14 μM Compound: 21a	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 72 hrs Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 72 hrs	[PMID: 37572539]
MOLM-13	IC₅₀	0.16 μM Compound: 21a	Antiproliferative activity against human MOLM-13 cells assessed as reduction in cell viability measured after 72 hrs Antiproliferative activity against human MOLM-13 cells assessed as reduction in cell viability measured after 72 hrs	[PMID: 37572539]
MV4-11	IC₅₀	0.06 μM Compound: 21a	Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability measured after 72 hrs Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability measured after 72 hrs	[PMID: 37572539]
SW480	IC₅₀	3.45 μM Compound: 21a	Antiproliferative activity against human SW480 cells assessed as reduction in cell viability measured after 72 hrs Antiproliferative activity against human SW480 cells assessed as reduction in cell viability measured after 72 hrs	[PMID: 37572539]
THP-1	IC₅₀	0.45 μM Compound: 21a	Antiproliferative activity against human THP-1 cells assessed as reduction in cell viability measured after 72 hrs Antiproliferative activity against human THP-1 cells assessed as reduction in cell viability measured after 72 hrs	[PMID: 37572539]

Chemical Information

CAS No. 3052935-72-2
Molecular Weight 461.55
Formula C₂₇H₃₁N₃O₄
SMILES

CN(CC1)CC=C1C2=C3C(C(C=C(C4=CC=C(N5CCN(C)CC5)C=C4)O3)=O)=C(O)C=C2OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wu T, et al. Design and optimization of selective and potent CDK9 inhibitors with flavonoid scaffold for the treatment of acute myeloid leukemia. Eur J Med Chem. 2023 Nov 5;259:115711. [Content Brief]

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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