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製品番号: HY-149870

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PROTAC CDK9 degrader-8

PROTAC CDK9 degrader-8 is a CDK9 PROTAC degrader that recruits cereblon. PROTAC CDK9 degrader-8 inhibits the growth of acute myeloid leukemia cells by inducing the degradation of CDK9 protein. PROTAC CDK9 degrader-8 can be used in studies related to CDK9-targeted degradation and acute myeloid leukemia.
(Pink: CDK9/Cyclin T ligand (HY-50940); Blue: Cereblon ligand (HY-103596); Black: linker).

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2994191-89-6
分子式: C₄₄H₅₂Cl₂N₁₀O₇
分子量:903.85

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

PROTAC CDK9 degrader-8 構造式

CAS 番号: 2994191-89-6

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

PROTAC CDK9 degrader-8 is a CDK9 PROTAC degrader that recruits cereblon. PROTAC CDK9 degrader-8 inhibits the growth of acute myeloid leukemia cells by inducing the degradation of CDK9 protein. PROTAC CDK9 degrader-8 can be used in studies related to CDK9-targeted degradation and acute myeloid leukemia^[1]. (Pink: CDK9/Cyclin T ligand (HY-50940); Blue: Cereblon ligand (HY-103596); Black: linker).

IC₅₀ & Target

^[1]

CDK9

PROTACs アイソフォーム固有の製品をすべて表示 :

CDK アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
MV4-11	IC50	0.01 μM	Inhibition of MV4-11 AML cell growth in standard conditions. Inhibition of MV4-11 AML cell growth in standard conditions.	37465296
MV4-11	IC50	8.8 nM	Inhibition of MV4-11 AML cell growth in fetal bovine serum (FBS). Inhibition of MV4-11 AML cell growth in fetal bovine serum (FBS).	37465296
MV4-11	IC50	28.6 nM	Inhibition of MV4-11 AML cell growth in human serum (HS). Inhibition of MV4-11 AML cell growth in human serum (HS).	37465296

体外実験

PROTAC CDK9 degrader-8 (compound 21) induces CDK9 degradation in MOLM-13 cells, with a DC₅₀ of 0.04 μM and a D_max of 88.6%^[1].
PROTAC CDK9 degrader-8 inhibits cell growth in MV4-11 acute myeloid leukemia cells, with an IC₅₀ of 0.01 μM^[1].
PROTAC CDK9 degrader-8 (6 h exposure followed by washout; total incubation time: 48 h) maintains cellular activity after washout in MV4-11 cells^[1].
PROTAC CDK9 degrader-8 exhibits an IC₅₀ of 8.8 nM in MV4-11 cells under FBS conditions and an IC₅₀ of 28.6 nM under human serum conditions, showing an approximately 3-fold serum shift, while still maintaining high cellular activity within this series under both conditions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 2994191-89-6
分子量 903.85
分子式 C₄₄H₅₂Cl₂N₁₀O₇
SMILES

O=C(C1=NNC=C1NC(C2=C(Cl)C=CC=C2Cl)=O)NC3CCN(CCCCCCCCCCC4=CN(CCCOC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)N=N4)CC3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (274 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Ayinde OR, et al. Examination of the Impact of Triazole Position within Linkers on Solubility and Lipophilicity of a CDK9 Degrader Series. ACS medicinal chemistry letters. 2023 Jul 13;14(7):936-942. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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