1. PROTAC
    Cell Cycle/DNA Damage
  2. PROTAC
    CDK
  3. PROTAC CDK9 Degrader-1

PROTAC CDK9 Degrader-1 

Cat. No.: HY-103628 Purity: 99.04%
Handling Instructions

PROTAC CDK9 Degrader-1 is a selective CDK9 degrader.

For research use only. We do not sell to patients.

PROTAC CDK9 Degrader-1 Chemical Structure

PROTAC CDK9 Degrader-1 Chemical Structure

CAS No. : 2118356-96-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 608 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

PROTAC CDK9 Degrader-1 is a selective CDK9 degrader.

IC50 & Target[1]

CDK9

 

In Vitro

PROTAC CDK9 Degrader-1 (Compound 3; 2.5-20 μM; 6 hours) degrades CDK9 in a dose dependent manner in HCT116 cells[1].

Western Blot Analysis[1]

Cell Line: HCT116 cells
Concentration: 2.5, 5, 10, and 20μM
Incubation Time: 6 hours
Result: Degraded CDK9 in a dose dependent manner.
Molecular Weight

613.66

Formula

C₃₃H₃₅N₅O₇

CAS No.

2118356-96-8

SMILES

O=C(CC1=CC=C(OCCCCCOC2=CC=CC(C(N3C4C(NC(CC4)=O)=O)=O)=C2C3=O)C=C1)NC5=CC(C6CCC6)=NN5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 104 mg/mL (169.47 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6296 mL 8.1478 mL 16.2957 mL
5 mM 0.3259 mL 1.6296 mL 3.2591 mL
10 mM 0.1630 mL 0.8148 mL 1.6296 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.07 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.07 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.04%

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Keywords:

PROTAC CDK9 Degrader-1PROTACCDKProteolysis-targeting chimeraCyclin dependent kinaseInhibitorinhibitorinhibit

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Product name:
PROTAC CDK9 Degrader-1
Cat. No.:
HY-103628
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