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Cat. No.: HY-183699

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CDK9-IN-52

CDK9-IN-52 is a CDK9 inhibitor. CDK9-IN-52 exhibits antiproliferative activity against cancer cells. CDK9-IN-52 can be used in studies related to lung cancer, cervical cancer, and breast cancer.

For research use only. We do not sell to patients.

Formula: C₂₄H₁₇F₂N₃O
Molecular Weight:401.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CDK9-IN-52 Chemical Structure

Size

Price

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Quantity

Sample (0.1mg)

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(In Japan)

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

CDK9-IN-52 is a CDK9 inhibitor. CDK9-IN-52 exhibits antiproliferative activity against cancer cells. CDK9-IN-52 can be used in studies related to lung cancer, cervical cancer, and breast cancer^[1].

IC₅₀ & Target^[1]

CDK9

All CDK Isoforms :

In Vitro

CDK9-IN-52 (D6) potently inhibits the proliferation of HeLa, A549, SiHa and MCF-7 cancer cells with IC₅₀ values of 6.64, 7.27, 10.36 and 10.82 μM, respectively. Meanwhile, it exhibits selective cytotoxicity toward cancer cells compared with normal HEK-293t cells, with the highest selectivity against HeLa cells (SI=9.1)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 401.41
Formula C₂₄H₁₇F₂N₃O
SMILES

N#CC1=CC(C(C=C2)=CC(F)=C2NC(CCN3C(C=CC(F)=C4)=C4C=C3)=O)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Reddyrajula R, et al. Development of potential CDK9 inhibitors through pharmacophore-based virtual screening, 3D-QSAR, molecular docking, MD simulation, and in vitro anticancer evaluation. Sci Rep. Published online April 28, 2026. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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