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JMJD6 - jumonji domain containing 6, arginine demethylase and lysine hydroxylase Gene

Also Known as PSR; PTDSR; PTDSR1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23210

About JMJD6

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:76,712,836-76,726,606 (from NCBI)

This gene has 8 transcripts (splice variants), 209 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 17.6), heart (RPKM 4.9) and 24 other tissues.

Summary

This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells; however, subsequent studies have indicated that it does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

JMJD6 Products (2)

mRNA	Protein	Name
NM_001081461.2	NP_001074930.1	bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 isoform 1
NM_015167.3	NP_055982.2	bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables P-TEFb complex binding	IDA IDA: Inferred from direct assay	24360279	GOA
enables histone H3R2 demethylase activity	IDA IDA: Inferred from direct assay	17947579	GOA
enables histone H4R3 demethylase activity	IDA IDA: Inferred from direct assay	17947579	GOA
enables histone demethylase activity	IDA IDA: Inferred from direct assay	24498420	GOA
enables identical protein binding	IDA IDA: Inferred from direct assay	17534701	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	24360279	GOA
enables iron ion binding	IDA IDA: Inferred from direct assay	20679243	GOA
enables oxidative RNA demethylase activity	IMP IMP: Inferred from mutant phenotype	24360279	GOA
enables peptidyl-lysine 5-dioxygenase activity	EXP EXP: Inferred from Experiment	23303181	GOA
enables peptidyl-lysine 5-dioxygenase activity	IDA IDA: Inferred from direct assay	19574390	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19574390	GOA
enables protein demethylase activity	IDA IDA: Inferred from direct assay	24498420	GOA
enables single-stranded RNA binding	IDA IDA: Inferred from direct assay	20679243	GOA
enables transcription regulator activator activity	IMP IMP: Inferred from mutant phenotype	21555454	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	17947579	GOA
involved in oxidative RNA demethylation	IDA IDA: Inferred from direct assay	24360279	GOA
involved in peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine	IDA IDA: Inferred from direct assay	19574390	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	21555454	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	24360279	GOA
involved in protein homooligomerization	IDA IDA: Inferred from direct assay	22189873	GOA
involved in regulation of mRNA splicing, via spliceosome	IMP IMP: Inferred from mutant phenotype	19574390	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	24498420	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	21060799	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	21060799	GOA
located in nucleus	IDA IDA: Inferred from direct assay	14729065	GOA
located in nucleus	IMP IMP: Inferred from mutant phenotype	21555454	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

JMJD6 Protein Structure

JmjC

0
100
200
300
403 a.a.

Protein Preferred Names	Protein Names
bifunctional arginine demethylase and lysyl-hydroxylase JMJD6	arginine demethylase and lysine hydroxylase

JMJD6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	JMJD6	Q6NYC1	NAA50	Homo sapiens	Q9GZZ1	Validated Y2H	32296183
Intra	JMJD6	Q6NYC1	NAA50	Homo sapiens	Q9GZZ1	Y2H Array	25416956
Intra	JMJD6	Q6NYC1	NAA50	Homo sapiens	Q9GZZ1	Y2H Prey Pooling	25416956
Intra	JMJD6	Q6NYC1	CDK9	Homo sapiens	P50750	Anti Tag CoIP	24360279
Intra	JMJD6	Q6NYC1	CARM1	Homo sapiens	Q86X55	Anti Tag CoIP	24498420
Intra	JMJD6	Q6NYC1	ARGLU1	Homo sapiens	Q9NWB6	Anti Tag CoIP	33961781
Intra	JMJD6	Q6NYC1	CCNL1	Homo sapiens	Q9UK58	Anti Tag CoIP	33961781
Intra	JMJD6	Q6NYC1	TP53	Homo sapiens	P04637	Anti Tag CoIP	24667498
Intra	JMJD6	Q6NYC1	TP53	Homo sapiens	P04637	Pull Down	24667498
Intra	JMJD6	Q6NYC1	TP53	Homo sapiens	P04637	Hydroxylase Assay	24667498
Intra	JMJD6	Q6NYC1	TP53	Homo sapiens	P04637	Anti Bait CoIP	24667498
Intra	JMJD6	Q6NYC1	U2AF1	Homo sapiens	Q01081	Anti Tag CoIP	33961781
Intra	JMJD6	Q6NYC1	RSRC1	Homo sapiens	Q96IZ7	Anti Tag CoIP	33961781
Intra	JMJD6	Q6NYC1	RSRC1	Homo sapiens	Q96IZ7	Y2H	23455924
Intra	JMJD6	Q6NYC1	PRPF38A	Homo sapiens	Q8NAV1	Y2H	23455924
Intra	JMJD6	Q6NYC1	PRPF38A	Homo sapiens	Q8NAV1	Anti Tag CoIP	33961781
Intra	JMJD6	Q6NYC1	BRD4	Homo sapiens	O60885	Anti Bait CoIP	24360279
Intra	JMJD6	Q6NYC1	BRD4	Homo sapiens	O60885	Anti Tag CoIP	24360279
Intra	JMJD6	Q6NYC1	BRD4	Homo sapiens	O60885	Anti Tag CoIP	33961781
Intra	JMJD6	Q6NYC1	BRD4	Homo sapiens	O60885	Pull Down	24360279
Intra	JMJD6	Q6NYC1	ZCCHC17	Homo sapiens	Q9NP64	Y2H	23455924
Intra	JMJD6	Q6NYC1	ZCCHC17	Homo sapiens	Q9NP64	Anti Tag CoIP	33961781
Intra	JMJD6	Q6NYC1	ESR1	Homo sapiens	P03372	Anti Bait CoIP	24498420
Intra	JMJD6	Q6NYC1	ESR1	Homo sapiens	P03372	Demethylase Assay	24498420
Intra	JMJD6	Q6NYC1	ESR1	Homo sapiens	P03372	Pull Down	24498420
Intra	JMJD6	Q6NYC1	ESR1	Homo sapiens	P03372	PLA	24498420

Cross: Cross-species interaction Intra: Intraspecies interaction

JMJD6 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81319	JMJD6 Antibody (YA1064)	WB, ICC/IF	Human
HY-P81319A	JMJD6 Antibody (YA1064)(PBS only)	WB, ICC/IF	Human
HY-P85461	JMJD6 Antibody (YA5153)	WB, ICC/IF	Human, Mouse, Rat, Bovine, Dog
HY-P85485	JMJD6(N-term) Antibody (YA5177)	WB, ICC/IF	Human

Related Diseases

Diseases	Alias
Myasthenic Syndrome, Congenital, 9, Associated With Acetylcholine Receptor Deficiency	Congenital Myasthenic Syndrome 9 CMS9 Congenital Myasthenic Syndrome 9, Associated With Acetylcholine Receptor Deficiency Myasthenic Syndrome, Congenital, Type 9, Associated With Acetylcholine Receptor Deficiency
Pancreatitis	Mumps Pancreatitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-139782	SKLB325		99.21%	Unkown
HY-139434	JMJD6-IN-1	Inhibitor	99.51%	Unkown
HY-P10446	TAT-PiET-PROTAC	Inhibitor	98.04%	Unkown
HY-P10445	TAT-PiET	Inhibitor	/	Unkown
HY-RS07039	JMJD6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17009	Jmjd6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23452	Jmjd6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	JMJD6	VGNC	VGNC:73862
Canis familiaris	JMJD6	VGNC	VGNC:42189
Bos taurus	JMJD6	VGNC	VGNC:30377
Rattus norvegicus	JMJD6	RGD	RGD:1305395
Mus musculus	JMJD6	MGD	MGI:1858910
Others	JMJD6	NCBI