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NAA50 - N-alpha-acetyltransferase 50, NatE catalytic subunit Gene

Also Known as SAN; MAK3; NAT5; NAT13; NAT5P; NAT13P; hNaa50p

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 80218

About NAA50

Cytogenetic location: 3q13.31 Genomic coordinates (GRCh38): 3:113,716,458-113,746,249 (from NCBI)

This gene has 10 transcripts (splice variants), 246 orthologues and 4 paralogues. Ubiquitous expression in esophagus (RPKM 21.2), fat (RPKM 20.2) and 25 other tissues.

Summary

Enables H4 Histone Acetyltransferase activity; peptide alpha-N-acetyltransferase activity; and peptidyl-lysine acetyltransferase activity. Involved in N-terminal protein amino acid acetylation; establishment of mitotic sister chromatid cohesion; and mitotic sister chromatid cohesion, centromeric. Located in cytosol and nucleus. Part of NatA complex. [provided by Alliance of Genome Resources, Apr 2022]

NAA50 Products (2)

mRNA	Protein	Name
NM_001308445.2	NP_001295374.1	N-alpha-acetyltransferase 50 isoform 2
NM_025146.4	NP_079422.1	N-alpha-acetyltransferase 50 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables histone H4 acetyltransferase activity	IDA IDA: Inferred from direct assay	19744929	GOA
enables peptide alpha-N-acetyltransferase activity	IDA IDA: Inferred from direct assay	17502424	GOA
enables peptide alpha-N-acetyltransferase activity	IMP IMP: Inferred from mutant phenotype	27422821	GOA
enables peptide-lysine-N-acetyltransferase activity	IDA IDA: Inferred from direct assay	19744929	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16507339	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in N-terminal protein amino acid acetylation	IDA IDA: Inferred from direct assay	21900231	GOA
involved in N-terminal protein amino acid acetylation	IMP IMP: Inferred from mutant phenotype	27422821	GOA
involved in establishment of mitotic sister chromatid cohesion	IDA IDA: Inferred from direct assay	27422821	GOA
involved in mitotic sister chromatid cohesion, centromeric	IDA IDA: Inferred from direct assay	17502424	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of NatA complex	IDA IDA: Inferred from direct assay	16507339	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16507339	GOA
located in cytosol	IDA IDA: Inferred from direct assay	27422821	GOA
located in nucleus	IDA IDA: Inferred from direct assay	25732826	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NAA50 Protein Structure

Acetyltransf_1

0
100
169 a.a.

Protein Preferred Names	Protein Names
N-alpha-acetyltransferase 50	N-acetyltransferase 13 (GCN5-related)

NAA50 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NAA50	Q9GZZ1	NAA15	Homo sapiens	Q9BXJ9	Anti Tag CoIP	33961781
Intra	NAA50	Q9GZZ1	NAA15	Homo sapiens	Q9BXJ9	Anti Bait CoIP	16507339
Intra	NAA50	Q9GZZ1	NAA15	Homo sapiens	Q9BXJ9	Pull Down	16507339
Intra	NAA50	Q9GZZ1	NAA16	Homo sapiens	Q6N069	Anti Tag CoIP	33961781
Intra	NAA50	Q9GZZ1	BHLHE40	Homo sapiens	O14503	Y2H Prey Pooling	32296183
Intra	NAA50	Q9GZZ1	BHLHE40	Homo sapiens	O14503	Validated Y2H	25416956
Intra	NAA50	Q9GZZ1	BHLHE40	Homo sapiens	O14503	Y2H Array	32296183
Intra	NAA50	Q9GZZ1	NAA10	Homo sapiens	P41227	Pull Down	16507339
Intra	NAA50	Q9GZZ1	NAA10	Homo sapiens	P41227	Anti Tag CoIP	33961781
Intra	NAA50	Q9GZZ1	JMJD6	Homo sapiens	Q6NYC1	Validated Y2H	25416956
Intra	NAA50	Q9GZZ1	JMJD6	Homo sapiens	Q6NYC1	Y2H Prey Pooling	32296183
Intra	NAA50	Q9GZZ1	JMJD6	Homo sapiens	Q6NYC1	Y2H Array	32296183
Intra	NAA50	Q9GZZ1	OTX2	Homo sapiens	P32243-2	Y2H Prey Pooling	32296183
Intra	NAA50	Q9GZZ1	OTX2	Homo sapiens	P32243-2	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Ogden Syndrome	OGDNS N-Terminal Acetyltransferase Deficiency NATD N-Alpha-Acetyltransferase X-Linked Malformation And Infantile Lethality Syndrome Premature Aging Appearance-Developmental Delay-Cardiac Arrhythmia Syndrome
Neurogenic Arthropathy	Neuropathic Arthropathy Arthropathy Associated With Neurological Disorder Charcot'S Arthropathy Charcot'S Joint Arthropathy, Neurogenic Charcot Joint Charcot Or Tabetic Arthropathy Charcot Foot
Villonodular Synovitis	Pigmented Villonodular Synovitis
Ochronosis
Microphthalmia, Syndromic 1	MCOPS1 Lenz Microphthalmia Syndrome Lenz Dysplasia Mcops4 Syndromic Microphthalmia 1 Lenz Microphthalmia Maa Microphthalmia Or Anophthalmos With Associated Anomalies Syndromic Microphthalmia Type 4 Microphthalmia, Syndromic 4 Microphthalmia, Syndromic 4, Formerly Mcops4, Formerly Anop1, Formerly Maa, Formerly Lenz Type Microphthalmia Syndromic Microphthalmia 4 Microphthalmia Lenz Type Microphthalmia Syndromic 1 Syndromic Microphthalmia Type 1 Microphthalmia Syndromic 4 Microphthalmia With Ankyloblepharon And Intellectual Disability Microphthalmia, Lenz Type Microphthalmia-Ankyloblepharon-Intellectual Disability Syndrome Microphthalmia, Syndromic, 1 Anop1 Microphthalmia, Syndromic, Type 1
Syndromic Microphthalmia	Microphthalmia, Syndromic
Crouzon Syndrome With Acanthosis Nigricans	Crouzon Syndrome-Acanthosis Nigricans Syndrome CAN Crouzonodermoskeletal Syndrome Crouzon-Dermoskeletal Syndrome Crouzon, With Acanthosis Nigricans Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-156140	Naa50-IN-1	Inhibitor	99.94%	Unkown
HY-RS08991	NAA50 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18532	Naa50 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25014	Naa50 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NAA50	VGNC	VGNC:96706
Macaca mulatta	NAA50	VGNC	VGNC:110351
Bos taurus	NAA50	VGNC	VGNC:53590
Rattus norvegicus	NAA50	RGD	RGD:1310944
Mus musculus	NAA50	MGD	MGI:1919367
Others	NAA50	NCBI