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NAA15 - N-alpha-acetyltransferase 15, NatA auxiliary subunit Gene

Also Known as Ga19; NATH; TBDN; MRD50; NARG1; NAT1P; TBDN100

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 80155

About NAA15

Cytogenetic location: 4q31.1 Genomic coordinates (GRCh38): 4:139,301,505-139,391,384 (from NCBI)

This gene has 15 transcripts (splice variants), 273 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 10.4), lymph node (RPKM 9.1) and 25 other tissues.

Summary

N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes the auxillary subunit of the N-terminal acetyltransferase A (NatA) complex. [provided by RefSeq, Jan 2017]

NAA15 Products (2)

mRNA	Protein	Name
NM_001410842.1	NP_001397771.1	N-alpha-acetyltransferase 15, NatA auxiliary subunit isoform 2
NM_057175.5	NP_476516.1	N-alpha-acetyltransferase 15, NatA auxiliary subunit isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
contributes to acetyltransferase activity	IDA IDA: Inferred from direct assay	15496142	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12145306	GOA
contributes to ribosome binding	IDA IDA: Inferred from direct assay	15496142	GOA
enables ribosome binding	IDA IDA: Inferred from direct assay	19480662	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in N-terminal protein amino acid acetylation	IDA IDA: Inferred from direct assay	15496142	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	19480662	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12145306	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	19480662	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of NatA complex	IDA IDA: Inferred from direct assay	15496142	GOA
part of NatA complex	IPI IPI: Inferred from physical interaction	15496142	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	12140756	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12140756	GOA
part of transcription regulator complex	IDA IDA: Inferred from direct assay	12145306	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NAA15 Protein Structure

TPR_2

NARP1

0
200
400
600
800
866 a.a.

Protein Preferred Names	Protein Names
N-alpha-acetyltransferase 15, NatA auxiliary subunit	N-terminal acetyltransferase

NAA15 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NAA15	Q9BXJ9	HYPK	Homo sapiens	Q9NX55	Anti Tag CoIP	28514442
Intra	NAA15	Q9BXJ9	HYPK	Homo sapiens	Q9NX55	Validated Y2H	32296183
Intra	NAA15	Q9BXJ9	HYPK	Homo sapiens	Q9NX55	Y2H Prey Pooling	32296183
Intra	NAA15	Q9BXJ9	HYPK	Homo sapiens	Q9NX55	Y2H Array	32296183
Intra	NAA15	Q9BXJ9	NAA50	Homo sapiens	Q9GZZ1	Anti Tag CoIP	33961781
Intra	NAA15	Q9BXJ9	NAA50	Homo sapiens	Q9GZZ1	Anti Tag CoIP	28514442
Intra	NAA15	Q9BXJ9	NAA11	Homo sapiens	Q9BSU3	Anti Tag CoIP	16638120
Intra	NAA15	Q9BXJ9	NAA10	Homo sapiens	P41227	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Intellectual Developmental Disorder, Autosomal Dominant 50, With Behavioral Abnormalities	Mental Retardation, Autosomal Dominant 50 MRD50 Autosomal Dominant Intellectual Developmental Disorder 50 Autosomal Dominant Intellectual Developmental Disorder-50 With Behavioral Abnormalities Autosomal Dominant Mental Retardation 50
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Ogden Syndrome	OGDNS N-Terminal Acetyltransferase Deficiency NATD N-Alpha-Acetyltransferase X-Linked Malformation And Infantile Lethality Syndrome Premature Aging Appearance-Developmental Delay-Cardiac Arrhythmia Syndrome
Microphthalmia, Syndromic 1	MCOPS1 Lenz Microphthalmia Syndrome Lenz Dysplasia Mcops4 Syndromic Microphthalmia 1 Lenz Microphthalmia Maa Microphthalmia Or Anophthalmos With Associated Anomalies Syndromic Microphthalmia Type 4 Microphthalmia, Syndromic 4 Microphthalmia, Syndromic 4, Formerly Mcops4, Formerly Anop1, Formerly Maa, Formerly Lenz Type Microphthalmia Syndromic Microphthalmia 4 Microphthalmia Lenz Type Microphthalmia Syndromic 1 Syndromic Microphthalmia Type 1 Microphthalmia Syndromic 4 Microphthalmia With Ankyloblepharon And Intellectual Disability Microphthalmia, Lenz Type Microphthalmia-Ankyloblepharon-Intellectual Disability Syndrome Microphthalmia, Syndromic, 1 Anop1 Microphthalmia, Syndromic, Type 1
Intellectual Developmental Disorder, Autosomal Dominant 10	MRD10 Mental Retardation, Autosomal Dominant 10 Autosomal Dominant Non-Syndromic Intellectual Disability 10 Autosomal Dominant Intellectual Developmental Disorder 10 Autosomal Dominant Mental Retardation 10 Mental Retardation, Autosomal Dominant, Type 10
Microcephaly And Chorioretinopathy 2
Syndromic Microphthalmia	Microphthalmia, Syndromic
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Uterine Corpus Endometrial Carcinoma
Smith-Mccort Dysplasia 1	Smith-Mccort Dysplasia SMC1 Smc Smith Mccort Dysplasia Smith-Mccort Dwarfism
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08986	NAA15 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NAA15	VGNC	VGNC:78529
Bos taurus	NAA15	VGNC	VGNC:53913
Rattus norvegicus	NAA15	RGD	RGD:1310984
Macaca mulatta	NAA15	VGNC	VGNC:96715
Canis familiaris	NAA15	VGNC	VGNC:54810
Mus musculus	NAA15	MGD	MGI:1922088
Others	NAA15	NCBI