CCNT1 - cyclin T1 Gene

Also Known as CCNT; CYCT1; HIVE1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 904

About CCNT1

Cytogenetic location: 12q13.11-q13.12 Genomic coordinates (GRCh38): 12:48,688,458-48,716,707 (from NCBI)

This gene has 6 transcripts (splice variants), 224 orthologues and 6 paralogues. Ubiquitous expression in bone marrow (RPKM 11.5), testis (RPKM 9.4) and 25 other tissues.

Summary

This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, there are multiple forms of positive transcription elongation factor b, which may include one of several different cyclins along with cyclin-dependent kinase 9. The complex containing the encoded cyclin and cyclin-dependent kinase 9 acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and is both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the largest RNA polymerase II subunit. Overexpression of this gene is implicated in tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

CCNT1 Products (5)

mRNA Protein Name
NM_001240.4 NP_001231.2 cyclin-T1 isoform a
NM_001277842.2 NP_001264771.1 cyclin-T1 isoform b
NM_001413198.1 NP_001400127.1 cyclin-T1 isoform c
NM_001413199.1 NP_001400128.1 cyclin-T1 isoform d
NM_001413200.1 NP_001400129.1 cyclin-T1 isoform e

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 7SK snRNA binding IDA
IDA: Inferred from direct assay
11713533 GOA
enables DNA binding IDA
IDA: Inferred from direct assay
16109376 GOA
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
25116364 GOA
enables RNA polymerase binding IPI
IPI: Inferred from physical interaction
15563843 GOA
enables cyclin-dependent protein serine/threonine kinase activator activity IDA
IDA: Inferred from direct assay
29849146 GOA
enables molecular condensate scaffold activity IDA
IDA: Inferred from direct assay
29849146 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9499409 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation by host of viral transcription IDA
IDA: Inferred from direct assay
10866664 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15563843 GOA
involved in positive regulation of transcription elongation by RNA polymerase II IDA
IDA: Inferred from direct assay
9499409 GOA
Cellular Component GO Annotation Evidence References Source
part of P-TEFb complex IDA
IDA: Inferred from direct assay
18483487 GOA
part of cyclin/CDK positive transcription elongation factor complex IDA
IDA: Inferred from direct assay
9499409 GOA
part of cyclin/CDK positive transcription elongation factor complex IPI
IPI: Inferred from physical interaction
18566585 GOA
NOT located in nucleolus IDA
IDA: Inferred from direct assay
16109376 GOA
is active in nucleus IDA
IDA: Inferred from direct assay
29849146 GOA
located in nucleus IDA
IDA: Inferred from direct assay
12944466 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCNT1 Protein Structure

Cyclin_N

Cyclin_N: Cyclin, N-terminal domain (13 - 149)

  • 0
  • 200
  • 400
  • 600
  • 726 a.a.
Protein Preferred Names Protein Names

cyclin-T1

  • CDK9-associated C-type protein

CCNT1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CCNT1 O60563 CDK9 Homo sapiens P50750
X-Ray Diffraction
20535204
Intra
CCNT1 O60563 CDK9 Homo sapiens P50750
Anti Tag CoIP
26659056
Intra
CCNT1 O60563 CDK9 Homo sapiens P50750
CoIP
9491887
Intra
CCNT1 O60563 CDK9 Homo sapiens P50750
Pull Down
18483487
Intra
CCNT1 O60563 CDK9 Homo sapiens P50750
Anti Bait CoIP
20562857
Intra
CCNT1 O60563 CDK9 Homo sapiens P50750
Anti Bait CoIP
19387490
Intra
CCNT1 O60563 CDK9 Homo sapiens P50750
Ion Exchange Chrom
20535204
Intra
CCNT1 O60563 CDK9 Homo sapiens P50750
Anti Tag CoIP
19387490
Intra
CCNT1 O60563 CDK9 Homo sapiens P50750
Anti Bait CoIP
18483487
Intra
CCNT1 O60563 HEXIM1 Homo sapiens O94992
NMR
17724342
Intra
CCNT1 O60563 HEXIM1 Homo sapiens O94992
Anti Tag CoIP
19387490
Intra
CCNT1 O60563 HEXIM1 Homo sapiens O94992
Anti Bait CoIP
19387490
Intra
CCNT1 O60563 HEXIM1 Homo sapiens O94992
Anti Bait CoIP
18483487
Intra
CCNT1 O60563 AFF4 Homo sapiens Q9UHB7
Anti Tag CoIP
20153263
Cross
CCNT1 O60563 tat Human immunodeficiency virus P04608
Ion Exchange Chrom
20535204
Cross
CCNT1 O60563 tat Human immunodeficiency virus P04608
X-Ray Diffraction
20535204
Cross: Cross-species interaction Intra: Intraspecies interaction

CCNT1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82855 Cyclin T1 Antibody (YA2600) WB, IHC-F, IHC-P, ICC/IF, IP Human, Mouse, Rat
HY-P82855A Cyclin T1 Antibody (YA2600)(PBS only) WB, IHC-F, IHC-P, ICC/IF, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Human Immunodeficiency Virus Type 1

  • Aids

  • Hiv/Aids

  • Aids, Delayed/Rapid Progression To

  • Hiv-1, Susceptibility To

  • Hiv-1 Viremia, Susceptibility To

  • Human Immunodeficiency Virus Type 1, Susceptibility To

  • Hiv-1

  • Aids, Slow Progression To

  • Rapid Progression To Aids From Hiv1 Infection

  • Hiv1 Infection, Resistance To

  • Hiv1 Infection

  • Hiv-1 Viremia

  • Aids, Resistance To

  • Aids, Rapid Progression To

  • Hiv/Aids, Susceptibility To

  • Hiv-1, Resistance To

  • Hiv1, Resistance To

  • Hiv1

  • Hiv-1 Disease, Delayed Progression Of

  • Hiv-1 Disease, Rapid Progression Of

  • Hiv Infection, Resistance To

  • Hiv Type 1, Susceptibility To

  • Hiv Type 1

  • Hiv-1 Infection

  • Human Immunodeficiency Virus I Infection

  • Acquired Immunodeficiency Syndrome

  • Hiv-Infection/Aids
Immune Deficiency Disease

  • Immunodeficiency

  • Primary Immunodeficiency

  • Primary Immunodeficiency Disease

  • Immunologic Deficiency Syndromes

  • Hypoimmunity

  • Immune Deficiency Disorder

  • Immunodeficiency Syndrome

  • Immune Disorder

  • Primary Immune Deficiency Disorder

  • Immune System Diseases

  • Human Immunodeficiency Virus Infection

  • Hiv - [Human Immunodeficiency Virus Infection]

  • Hiv Positive Nos

  • Hiv Disease

  • Acquired Immune Deficiency Syndrome-Related Complex

  • Aids-Like Syndrome

  • Aids-Related Complex Nos

  • Arc - [Aids-Related Complex]

  • Immunodeficiency Due To Human Immunodeficiency Virus Infection

  • Unspecified Human Immunodeficiency Virus Disease

  • Hiv Disease Nos

  • Human Immunodeficiency Virus Positive Nos

  • Hiv Nos

  • Deficiency Of Complement Initial Pathway

  • Deficiency Of Complement Terminal Pathway

  • Cfdd - [Complement Factor D Deficiency]

  • Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency

  • Nonfamilial Hypogammaglobulinaemia

  • Common Variable Immune Deficiency

  • Nonfamilial Agammaglobulinaemia

  • Common Variable Agammaglobulinaemia

  • Agammaglobulinaemia Nos

  • Agammaglobulinaemia Antibody Deficiency Syndrome

  • Hypogammaglobulinaemia Antibody Deficiency Syndrome

  • Acquired Agammaglobulinaemia Nos

  • Hypogammaglobulinaemia Nos

  • Hyper Igm
Human Immunodeficiency Virus Infectious Disease

  • Hiv Infections
Nut Midline Carcinoma

  • Nuclear Protein In Testis Midline Carcinoma

  • Nmc
Leukemia, Chronic Lymphocytic

  • Chronic Lymphocytic Leukemia

  • B-Cell Chronic Lymphocytic Leukemia

  • CLL

  • B-Cell Chronic Lymphoid Leukemia

  • Chronic Lymphatic Leukemia

  • Chronic Lymphocytic Leukaemia

  • Lymphoplasmacytic Leukemia

  • Small Lymphocytic Lymphoma

  • Leukemia, Chronic Lymphatic

  • B-Cell Chronic Lymphocytic Leukaemia

  • Chronic Lymphatic Leukaemia

  • Lymphoplasmacytic Leukaemia

  • B Cell Chronic Lymphocytic Leukemia

  • Chronic B-Cell Lymphocytic Leukemia

  • Leukemia, Lymphocytic, Chronic

  • B-Cll

  • Chronic Lymphoid Leukemia

  • Leukemia Lymphocytic Chronic

  • Lymphoma Small Lymphocytic

  • Leukemia, Lymphocytic, Chronic, B-Cell
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-123972 SEC inhibitor KL-2 Inhibitor 99.49% Unkown
HY-122720 SEC inhibitor KL-1 Activator 99.58% Unkown
HY-RS02141 CCNT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21506 Ccnt1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28024 Ccnt1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CCNT1 VGNC VGNC:70735
Bos taurus CCNT1 VGNC VGNC:26978
Mus musculus CCNT1 MGD MGI:1328363
Rattus norvegicus CCNT1 RGD RGD:1311151
Canis familiaris CCNT1 VGNC VGNC:38906
Others CCNT1 NCBI