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SEC inhibitor KL-2 (Synonyms: KL-2)

Cat. No.: HY-123972
Handling Instructions

SEC inhibitor KL-2 (KL-2), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. SEC inhibitor KL-2 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with a Ki of 1.50 μM.

For research use only. We do not sell to patients.

SEC inhibitor KL-2 Chemical Structure

SEC inhibitor KL-2 Chemical Structure

CAS No. : 900308-51-2

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Description

SEC inhibitor KL-2 (KL-2), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. SEC inhibitor KL-2 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with a Ki of 1.50 μM[1].

IC50 & Target

SEC[1]

Molecular Weight

333.74

Formula

C₁₇H₁₃ClFNO₃

CAS No.

900308-51-2

SMILES

O=C(NC1=CC(Cl)=CC=C1C)/C(O)=C/C(C2=CC=C(F)C=C2)=O

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SEC inhibitor KL-2
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