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SEC inhibitor KL-2 (Synonyms: KL-2)

Cat. No.: HY-123972 Purity: 99.34%
Handling Instructions

SEC inhibitor KL-2 (KL-2), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. SEC inhibitor KL-2 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with a Ki of 1.50 μM.

For research use only. We do not sell to patients.

SEC inhibitor KL-2 Chemical Structure

SEC inhibitor KL-2 Chemical Structure

CAS No. : 900308-51-2

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 234 In-stock
Estimated Time of Arrival: December 31
1 mg USD 105 In-stock
Estimated Time of Arrival: December 31
5 mg USD 319 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

SEC inhibitor KL-2 (KL-2), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. SEC inhibitor KL-2 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with a Ki of 1.50 μM[1].

IC50 & Target

SEC[1]

Molecular Weight

333.74

Formula

C₁₇H₁₃ClFNO₃

CAS No.

900308-51-2

SMILES

O=C(NC1=CC(Cl)=CC=C1C)/C(O)=C/C(C2=CC=C(F)C=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (74.91 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9963 mL 14.9817 mL 29.9634 mL
5 mM 0.5993 mL 2.9963 mL 5.9927 mL
10 mM 0.2996 mL 1.4982 mL 2.9963 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.23 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.34%

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Keywords:

SEC inhibitor KL-2KL-2SEC inhibitor KL2SEC inhibitor KL 2KL2KL 2OthersInhibitorinhibitorinhibit

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Product Name:
SEC inhibitor KL-2
Cat. No.:
HY-123972
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