SEC inhibitor KL-2
Based on 1 publication(s) in Google Scholar
SEC inhibitor KL-2 (KL-2), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. SEC inhibitor KL-2 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with a Ki of 1.50 μM.
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- 純度 : 99.49%
- CAS 番号: 900308-51-2
- 分子式: C17H13ClFNO3
- 分子量:333.74
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 SEC inhibitor KL-2
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生物活性
製品説明
IC50 & Target
SEC[1]
体外実験
SEC inhibitor KL-2 (20 μM, 6 hours) significantly slows Pol II transcription elongation rates and increases Pol II accumulation at promoter-proximal regions in HEK293T cells[1]. SEC inhibitor KL-2 (20 μM, 24 hours) significantly inhibits MYC transcriptional programs and RNA splicing-related gene expressions in HEK293T cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:MDA231-LM2 xenograft tumor model in nude mice[1]
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Dosage:10 mg/kg
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Administration:Intraperitoneal injection (i.p.), once daily for 15 days
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Result:Significantly delayed tumor growth and increased survival of mice.
化学情報
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CAS 番号 900308-51-2
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性状 Solid
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分子量 333.74
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分子式 C17H13ClFNO3
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Color Light yellow to yellow
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SMILES
O=C(NC1=CC(Cl)=CC=C1C)/C(O)=C/C(C2=CC=C(F)C=C2)=O
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別名
KL-2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
溶剤 & 溶解度
体外:
DMSO : 83.33 mg/mL (249.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
体内:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
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データシート (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9963 mL | 14.9817 mL | 29.9634 mL | 74.9086 mL |
| 5 mM | 0.5993 mL | 2.9963 mL | 5.9927 mL | 14.9817 mL | |
| 10 mM | 0.2996 mL | 1.4982 mL | 2.9963 mL | 7.4909 mL | |
| 15 mM | 0.1998 mL | 0.9988 mL | 1.9976 mL | 4.9939 mL | |
| 20 mM | 0.1498 mL | 0.7491 mL | 1.4982 mL | 3.7454 mL | |
| 25 mM | 0.1199 mL | 0.5993 mL | 1.1985 mL | 2.9963 mL | |
| 30 mM | 0.0999 mL | 0.4994 mL | 0.9988 mL | 2.4970 mL | |
| 40 mM | 0.0749 mL | 0.3745 mL | 0.7491 mL | 1.8727 mL | |
| 50 mM | 0.0599 mL | 0.2996 mL | 0.5993 mL | 1.4982 mL | |
| 60 mM | 0.0499 mL | 0.2497 mL | 0.4994 mL | 1.2485 mL | |
| 80 mM | 0.0375 mL | 0.1873 mL | 0.3745 mL | 0.9364 mL | |
| 100 mM | 0.0300 mL | 0.1498 mL | 0.2996 mL | 0.7491 mL |
SEC inhibitor KL-2 関連分類
HY-123972 関連分類
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