900308-51-2
Chemical Structure
SEC inhibitor KL-2
Synonym(s): KL-2
- CAS No.: 900308-51-2
- Formula:C17H13ClFNO3
- Molecular Weight:333.74
IUPAC Name: (Z)-N-(5-chloro-2-methylphenyl)-4-(4-fluorophenyl)-2-hydroxy-4-oxobut-2-enamide
InChIKey: UTMIAXADLSTQRD-SXGWCWSVSA-N
SMILES: O=C(NC1=CC(Cl)=CC=C1C)/C(O)=C/C(C2=CC=C(F)C=C2)=O
Biological Activity: SEC inhibitor KL-2 (KL-2), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. SEC inhibitor KL-2 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with a Ki of 1.50 μM[1].
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SEC inhibitor KL-2 | 99.49% | SEC inhibitor KL-2 (KL-2), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. SEC inhibitor KL-2 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with a Ki of 1.50 μM. | ||||||||||||||||||||
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Keywords
