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SEC inhibitor KL-1 (Synonyms: KL-1)

Cat. No.: HY-122720 Purity: 99.67%
Handling Instructions

SEC inhibitor KL-1 (KL-1), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. SEC inhibitor KL-1 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with a Ki of 3.48 μM.

For research use only. We do not sell to patients.

SEC inhibitor KL-1 Chemical Structure

SEC inhibitor KL-1 Chemical Structure

CAS No. : 900308-84-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1  mL in DMSO USD 160 In-stock
Estimated Time of Arrival: December 31
5 mg USD 210 In-stock
Estimated Time of Arrival: December 31
10 mg USD 350 In-stock
Estimated Time of Arrival: December 31
25 mg USD 500 In-stock
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50 mg USD 750 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
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500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

SEC inhibitor KL-1 (KL-1), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. SEC inhibitor KL-1 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with a Ki of 3.48 μM[1].

IC50 & Target

SEC[1]

Molecular Weight

345.78

Formula

C₁₈H₁₆ClNO₄

CAS No.

900308-84-1

SMILES

O=C(NC1=CC(Cl)=CC=C1C)/C(O)=C/C(C2=CC=CC(OC)=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 41.67 mg/mL (120.51 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8920 mL 14.4601 mL 28.9201 mL
5 mM 0.5784 mL 2.8920 mL 5.7840 mL
10 mM 0.2892 mL 1.4460 mL 2.8920 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.08 mg/mL (6.02 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.02 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

SEC inhibitor KL-1KL-1SEC inhibitor KL1SEC inhibitor KL 1KL1KL 1OthersInhibitorinhibitorinhibit

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Product Name:
SEC inhibitor KL-1
Cat. No.:
HY-122720
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