900308-84-1
900308-84-1
Chemical Structure
SEC inhibitor KL-1
Synonym(s): KL-1
- CAS No.: 900308-84-1
- Formula:C18H16ClNO4
- Molecular Weight:345.78
IUPAC Name: (Z)-N-(5-chloro-2-methylphenyl)-2-hydroxy-4-(3-methoxyphenyl)-4-oxobut-2-enamide
InChIKey: XARMUWIFHJTYOC-YVLHZVERSA-N
SMILES: O=C(/C(O)=C/C(C1=CC=CC(OC)=C1)=O)NC2=CC(Cl)=CC=C2C
Biological Activity: SEC inhibitor KL-1 (KL-1) is a peptide-like lead compound that is an effective selective SEC inhibitor. SEC inhibitor KL-1 promotes apoptosis and has anti-tumor activity. SEC inhibitor KL-1 doses dependently inhibits the AFF4-CCNT1 interaction, with a Ki value of 3.48 μM[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SEC inhibitor KL-1 | 99.58% | SEC inhibitor KL-1 (KL-1) is a peptide-like lead compound that is an effective selective SEC inhibitor. SEC inhibitor KL-1 promotes apoptosis and has anti-tumor activity. SEC inhibitor KL-1 doses dependently inhibits the AFF4-CCNT1 interaction, with a Ki value of 3.48 μM. | ||||||||||||||||||||
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References
- [1]. Hiroaki Katagi, et al. Therapeutic targeting of transcriptional elongation in diffuse intrinsic pontine glioma. Neuro Oncol. 2021 Aug 2;23(8):1348-1359. [Content Brief]
- [2]. Liang K, et al. Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced CancerTherapy. Cell. 2018 Oct 18;175(3):766-779. [Content Brief]
