PROTAC CDK9 degrader-21
PROTAC CDK9 degrader-21 is a selective CDK9 PROTAC degrader. PROTAC CDK9 degrader-21 recruits the cereblon E3 ubiquitin ligase to specifically degrade CDK9 via the ubiquitin-proteasome pathway, thereby inhibiting tumor cell proliferation. PROTAC CDK9 degrader-21 can be used for research on breast cancer, lymphoma, myeloma, leukemia, prostate cancer, and colon cancer.
(Pink: CDK9 ligand (HY-133697); Blue: Cereblon ligand (HY-103596); Black: linker (HY-W010047)).
For research use only. We do not sell to patients.
- CAS No.: 2411019-99-1
- Formula: C43H53N9O7
- Molecular Weight:807.94
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All PROTACs Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
CDK9 |
Cereblon |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDA-MB-468 | IC50 |
0.103 μM
|
Potently inhibits cell proliferation.
Potently inhibits cell proliferation.
|
WO2020035049A1 |
| BT-549 | IC50 |
0.071 μM
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Potently inhibits cell proliferation.
Potently inhibits cell proliferation.
|
WO2020035049A1 |
| OCI-Ly10 | IC50 |
0.036 μM
|
Potently inhibits cell proliferation.
Potently inhibits cell proliferation.
|
WO2020035049A1 |
| MM.1S | IC50 |
0.064 μM
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Potently inhibits cell proliferation.
Potently inhibits cell proliferation.
|
WO2020035049A1 |
| CCRF-CEM | IC50 |
0.054 μM
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Potently inhibits cell proliferation.
Potently inhibits cell proliferation.
|
WO2020035049A1 |
| PC-3 | IC50 |
0.055 μM
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Potently inhibits cell proliferation.
Potently inhibits cell proliferation.
|
WO2020035049A1 |
| HCT-116 | IC50 |
0.350 μM
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Potently inhibits cell proliferation.
Potently inhibits cell proliferation.
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WO2020035049A1 |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
- BrdU Incorporation Assay
- Somatic Cell Culture
- CFSE Dye Dilution Proliferation Assay
- Dye-dilution cell tracking and proliferation staining
- CCK-8/WST-8 Cell Proliferation Assay
- Protocol for Cell Cycle
- Cell Counting-Based Growth Curve Assay
- Colony Formation (Clonogenic) Assay
- Breast Cancer Modeling
- Cell Viability Determination by MTT Colorimetric Assay
- EdU Incorporation Assay (Click Chemistry-Based DNA Synthesis Measurement)
- Ki-67 Immunostaining Proliferation Assay
- PCNA Immunodetection Proliferation Assay
- Protocol for Cell Counting and Cell Density Analysis
- MTT Cell Proliferation Assay
Chemical Information
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CAS No. 2411019-99-1
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Molecular Weight 807.94
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Formula C43H53N9O7
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SMILES
CN1CCC(OC2=NC3=C(C(C)C)C=NN3C(NCC(C=C4)=CC=C4NC(CCCCCCCCOC5=CC=CC(C(N6C7C(NC(CC7)=O)=O)=O)=C5C6=O)=O)=N2)CC1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC CDK9 degrader-21 Related Classifications
HY-191291 Related Classifications
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