1. Cell Cycle/DNA Damage
  2. CDK
  3. CDK-IN-2

CDK-IN-2 (Synonyms: CDK inhibitor II)

Cat. No.: HY-13033 Purity: 97.54%
Handling Instructions

CDK-IN-2 is a potent and specific CDK9 inhibitor with IC50 of <8 nM, extracted from reference 1, example 4.

For research use only. We do not sell to patients.

CDK-IN-2 Chemical Structure

CDK-IN-2 Chemical Structure

CAS No. : 1269815-17-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 211 In-stock
Estimated Time of Arrival: December 31
2 mg USD 132 In-stock
Estimated Time of Arrival: December 31
5 mg USD 264 In-stock
Estimated Time of Arrival: December 31
10 mg USD 384 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1080 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

CDK-IN-2 is a potent and specific CDK9 inhibitor with IC50 of <8 nM, extracted from reference 1, example 4. IC50 Value: <8 nM [1] Target: CDK9 In vitro: In vivo:

IC50 & Target[1]

CDK9/cyclinT1

8 nM (IC50)

Molecular Weight

363.81

Formula

C₁₈H₁₉ClFN₃O₂

CAS No.

1269815-17-9

SMILES

FC1=CC(C2=CC(NC([[email protected]]3CNCCC3)=O)=NC=C2Cl)=C(C=C1)OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (274.87 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7487 mL 13.7434 mL 27.4869 mL
5 mM 0.5497 mL 2.7487 mL 5.4974 mL
10 mM 0.2749 mL 1.3743 mL 2.7487 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 3.25 mg/mL (8.93 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 3.25 mg/mL (8.93 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 3.25 mg/mL (8.93 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

CDK-IN-2CDK inhibitor IICDKCyclin dependent kinaseInhibitorinhibitorinhibit

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Product name:
CDK-IN-2
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HY-13033
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