1269815-17-9
1269815-17-9
Chemical Structure
CDK-IN-2
Synonym(s): CDK inhibitor II
- CAS No.: 1269815-17-9
- Formula:C18H19ClFN3O2
- Molecular Weight:363.81
IUPAC Name: (R)-N-(5-chloro-4-(5-fluoro-2-methoxyphenyl)pyridin-2-yl)piperidine-3-carboxamide
InChIKey: AHMKHNVZGOQLRQ-LLVKDONJSA-N
SMILES: FC1=CC(C2=CC(NC([C@H]3CNCCC3)=O)=NC=C2Cl)=C(C=C1)OC
Biological Activity: CDK-IN-2 is a specific CDK9 inhibitor with an IC50 of less than 8 nM. CDK-IN-2 reduces the phosphorylation level of H3S10. CDK-IN-2 decreases the transition rate of spermatocytes from prophase to metaphase I[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CDK-IN-2 | 99.27% | CDK-IN-2 is a specific CDK9 inhibitor with an IC50 of less than 8 nM. CDK-IN-2 reduces the phosphorylation level of H3S10. CDK-IN-2 decreases the transition rate of spermatocytes from prophase to metaphase I. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.59
HY-143585CDK9-IN-14 -
Similarity Score 0.59
HY-111537rel-AZ5576 -
Similarity Score 0.59
HY-143584AZ5576 -
Similarity Score 0.58
HY-153426CDK9-IN-23 -
Similarity Score 0.47
HY-1204692,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide -
Similarity Score 0.47
HY-121008Brl 20596 -
Similarity Score 0.47
HY-137081AKOS024836912 -
Similarity Score 0.47
HY-181811PJ17 -
Similarity Score 0.47
HY-112783TYK2 ligand 4 -
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