2. Neuronal Signaling Stem Cell/Wnt PI3K/Akt/mTOR
  3. Cholinesterase (ChE) GSK-3
  4. PJ17

PJ17 is a potent dual-target inhibitor of AChE and GSK-3β, with IC50 values of 8.84 μM and 4.19 μM, respectively. PJ17 shows no significant neurotoxic effect in primary cerebellar granule neuron cultures. PJ17 serves as a template for the design of multitarget drugs. PJ17 can be used for the research of Alzheimer's disease.

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PJ17

PJ17 Chemical Structure

CAS No. : 2248983-31-3

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PJ17 Related Antibodies

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Description

PJ17 is a potent dual-target inhibitor of AChE and GSK-3β, with IC50 values of 8.84 μM and 4.19 μM, respectively. PJ17 shows no significant neurotoxic effect in primary cerebellar granule neuron cultures. PJ17 serves as a template for the design of multitarget drugs. PJ17 can be used for the research of Alzheimer's disease[1].

IC50 & Target[1]

AChE

8.84 μM (IC50)

GSK-3β

4.19 μM (IC50)

In Vitro

PJ17 (30-100 μM) potently inhibits AChE with an IC50 of 8.84 μM[1].
PJ17 (10 μM) potently inhibits human recombinant GSK-3β with an IC50 of 4.19 μM, achieving 85.95% inhibition at 10 μM[1].
PJ17 (2.5-50 μM; 24-48 h) does not induce neurotoxicity in primary CGN cultures at concentrations up to 50 μM, and increases cell viability at 10-50 μM[1].
PJ17 (2.5-50 μM; 1-24 h pretreatment) does not exhibit significant neuroprotective activity against Rotenone (HY-B1756)-induced toxicity in primary CGN cultures at concentrations up to 50 μM[1].
PJ17 does not significantly inhibit rat MAO-A, MAO-B and human recombinant BACE-1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PJ17 Related Antibodies

Cell Viability Assay[1]

Cell Line: Primary cerebellar granule neurons (CGNs) cultures
Concentration: 2.5, 5, 10, 25, 50 μM
Incubation Time: 24 h, 48 h
Result: Showed no significant decrease in cell viability after 24 or 48 h of incubation at any tested concentration.
Increased cell viability at 10-50 μM.

Cell Viability Assay[1]

Cell Line: Primary cerebellar granule neurons (CGNs) cultures
Concentration: 2.5, 5, 10, 25, 50 μM
Incubation Time: 1 h pretreatment, 24 h pretreatment; 24 h Rotenone (HY-B1756) exposure
Result: Did not significantly prevent rotenone-induced cell viability reduction.
Molecular Weight

300.29

Formula

C15H13FN4O2
CAS No.
SMILES

O=C(C1CC1)NC2=NC=CC(C(NC3=C(C=NC=C3)F)=O)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PJ17 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PJ172248983-31-3PJ 17PJ-17Cholinesterase (ChE)GSK-3Glycogen synthase kinase-3Glycogen synthase kinase 3nAChR7primary cerebellar granule neuron culturesacetylcholinesterasehuman glycogen synthase kinase 3 betaelectric eel acetylcholinesteraseglycogen synthase kinase 3 betaBOSC-23 cellsAlzheimer's diseaseElectrophorus electricusGSK-3βInhibitorinhibitorinhibit

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