2248983-31-3
2248983-31-3
Chemical Structure
PJ17
- CAS No.: 2248983-31-3
- Formula:C15H13FN4O2
- Molecular Weight:300.29
InChIKey: WVIMSVZWOMJAKO-UHFFFAOYSA-N
SMILES: O=C(C1CC1)NC2=NC=CC(C(NC3=C(C=NC=C3)F)=O)=C2
Biological Activity: PJ17 is a potent dual-target inhibitor of AChE and GSK-3β, with IC50 values of 8.84 μM and 4.19 μM, respectively. PJ17 shows no significant neurotoxic effect in primary cerebellar granule neuron cultures. PJ17 serves as a template for the design of multitarget drugs. PJ17 can be used for the research of Alzheimer's disease[1].
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PJ17 | PJ17 is a potent dual-target inhibitor of AChE and GSK-3β, with IC50 values of 8.84 μM and 4.19 μM, respectively. PJ17 shows no significant neurotoxic effect in primary cerebellar granule neuron cultures. PJ17 serves as a template for the design of multitarget drugs. PJ17 can be used for the research of Alzheimer's disease. | |||||||||||||||||||||
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