AKOS024836912
AKOS024836912 is a EGFR-EGF interaction inhibitor. AKOS024836912 is applicable to research related to non-small cell lung cancer.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 1705763-81-0
- Fòrmula: C18H23N5O2
- Peso molecular:341.41
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Ver todos los productos específicos de isoformas EGFR
More
Actividad biológica
AKOS024836912 exhibits higher binding affinity to the EGF-binding cleft of EGFR (PDB ID: 1NQL) than its parent compound Dacomitinib (HY-13272), with a rearrangement score of -114.109[1].
AKOS024836912 inhibits the interaction between EGFR (PDB ID: 1NQL) and EGF, with a PatchDock score of 6115[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
No. CAS 1705763-81-0
-
Peso molecular 341.41
-
Fòrmula C18H23N5O2
-
SMILES
O=C(NC1=NC=NC(N2CCCCC2)=C1)NC3=CC(C)=CC=C3OC
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Gudala S, et al. Identification and Pharmacological Analysis of High Efficacy Small Molecule Inhibitors of EGF-EGFR Interactions in Clinical Treatment of Non-Small Cell Lung Carcinoma: a Computational Approach. Asian Pacific journal of cancer prevention : APJCP. 2015;16(18):8191-6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AKOS024836912 Related Classifications
HY-137081 Related Classifications
Powered by Bioz