CP-07
CP-07 is a potent and selective PROTACCDK9 degrader (DC50: 43 nM). CP-07 inhibits 22RV1 cell proliferation (IC50: 62 nM) and colony formation by down-regulating Mcl-1 and c-Myc. CP-07 inhibits 22RV1 xenograft tumor growth. CP-07 can be used for research of prostate cancer.
For research use only. We do not sell to patients.
- Formula: C45H48N6O8
- Molecular Weight:800.90
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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CDK9 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CWR22R | IC50 |
0.06 μM
Compound: CP-07
|
Antiproliferative activity against human 22Rv1 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
Antiproliferative activity against human 22Rv1 cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
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[PMID: 37672930] |
Chemical Information
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Molecular Weight 800.90
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Formula C45H48N6O8
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SMILES
COC1=CC(O)=C(C(C=C(C2=CC=C(N3CCN(CC4CCN(C5=CC=C(C(N(C6CCC(NC6=O)=O)C7=O)=O)C7=C5)CC4)CC3)C=C2)O8)=O)C8=C1C9=CCN(C)CC9
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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