CDK9-IN-51
CDK9-IN-51 is a CDK9 inhibitor. CDK9-IN-51 binds stably to purified CDK9 protein via interactions with key active-site residues Cys106, Asp109, and Phe103. CDK9-IN-51 exhibits antiproliferative activity against multiple cancer cells. CDK9-IN-51 can be used for the research of cancer, such as lung carcinoma, cervical carcinoma and breast carcinoma.
For research use only. We do not sell to patients.
- CAS No.: 2853500-43-1
- Formula: C21H16FN3O
- Molecular Weight:345.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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CDK9 |
CDK9-IN-51 (Compound D3) binds stably to purified CDK9 protein via interactions with key active-site residues Cys106, Asp109, and Phe103, with a binding free energy of -85.33 kcal/mol and a docking score of -9.186 kcal/mol[1].
CDK9-IN-51 potently inhibits the proliferation of multiple cancer cell lines, including A549, SiHa, and MCF-7, with
IC50 values of 6.09, 3.33, and 9.74 μM,
respectively, and exhibits minimal toxicity to normal HEK-293t cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2853500-43-1
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Molecular Weight 345.37
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Formula C21H16FN3O
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SMILES
FC(C=C(C1=CC=NC=C1)C=C2)=C2NC(CC3=CNC4=CC=CC=C43)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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