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製品番号: HY-183698

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CDK9-IN-51

CDK9-IN-51 is a CDK9 inhibitor. CDK9-IN-51 binds stably to purified CDK9 protein via interactions with key active-site residues Cys106, Asp109, and Phe103. CDK9-IN-51 exhibits antiproliferative activity against multiple cancer cells. CDK9-IN-51 can be used for the research of cancer, such as lung carcinoma, cervical carcinoma and breast carcinoma.

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CAS 番号: 2853500-43-1
分子式: C₂₁H₁₆FN₃O
分子量:345.37

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

CDK9-IN-51 構造式

CAS 番号: 2853500-43-1

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target^[1]

CDK9

CDK アイソフォーム固有の製品をすべて表示 :

体外実験

CDK9-IN-51 (Compound D3) binds stably to purified CDK9 protein via interactions with key active-site residues Cys106, Asp109, and Phe103, with a binding free energy of -85.33 kcal/mol and a docking score of -9.186 kcal/mol^[1].
CDK9-IN-51 potently inhibits the proliferation of multiple cancer cell lines, including A549, SiHa, and MCF-7, with
IC₅₀ values of 6.09, 3.33, and 9.74 μM,
respectively, and exhibits minimal toxicity to normal HEK-293t cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 2853500-43-1
分子量 345.37
分子式 C₂₁H₁₆FN₃O
SMILES

FC(C=C(C1=CC=NC=C1)C=C2)=C2NC(CC3=CNC4=CC=CC=C43)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Reddyrajula R, et al. Development of potential CDK9 inhibitors through pharmacophore-based virtual screening, 3D-QSAR, molecular docking, MD simulation, and in vitro anticancer evaluation. Sci Rep. Published online April 28, 2026. [Content Brief]

Calculators

モル濃度計算機

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

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CDK9-IN-51

CDK アイソフォーム固有の製品をすべて表示