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Cat. No.: HY-123826

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CCT68127

(Synonyms: αSβR-21)

CCT68127 is an orally active CDK inhibitor. CCT68127 can be used in anti-cancer research.

For research use only. We do not sell to patients.

CAS No.: 660822-23-1
Formula: C₁₉H₂₇N₇O
Molecular Weight:369.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

CCT68127 Chemical Structure

CAS No.: 660822-23-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

CCT68127 is an orally active CDK inhibitor. CCT68127 can be used in anti-cancer research^[1].

IC₅₀ & Target

CDK2

CDK7

CDK9

All CDK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HT-29	IC₅₀	1.3 μM Compound: alphaSbetaR-21, CCT68127	Inhibition of CDK7 in human HT29 cells assessed as reduction in RNA polymerase 2 expression Inhibition of CDK7 in human HT29 cells assessed as reduction in RNA polymerase 2 expression	[PMID: 21982796]
HT-29	IC₅₀	107 nM Compound: alphaSbetaR-21, CCT68127	Inhibition of CDK9 in human HT29 cells assessed as reduction in RNA polymerase 2 expression Inhibition of CDK9 in human HT29 cells assessed as reduction in RNA polymerase 2 expression	[PMID: 21982796]

Chemical Information

CAS No. 660822-23-1
Molecular Weight 369.46
Formula C₁₉H₂₇N₇O
SMILES

C[C@@H](O)[C@@H](NC1=NC(NCC2=CC=CN=C2)=C3N=CN(C(C)C)C3=N1)CC
Synonyms

αSβR-21
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wilson SC, et al. Design, synthesis and biological evaluation of 6-pyridylmethylaminopurines as CDK inhibitors. Bioorg Med Chem. 2011 Nov 15;19(22):6949-65. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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CCT68127

All CDK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

CCT68127 Related Classifications

HY-123826 Related Classifications