ZNF558 - zinc finger protein 558 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 148156

About ZNF558

This gene has 7 transcripts (splice variants), 157 orthologues and 62 paralogues. Ubiquitous expression in endometrium (RPKM 6.2), thyroid (RPKM 6.0) and 25 other tissues.

Summary

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

ZNF558 Products (2)

mRNA Protein Name
NM_001304350.2 NP_001291279.1 zinc finger protein 558 isoform 2
NM_144693.3 NP_653294.1 zinc finger protein 558 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF558 Protein Structure

KRAB

KRAB: KRAB box (43 - 83)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (166 - 191)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (195 - 218)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (222 - 246)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (250 - 275)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (279 - 302)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (307 - 331)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (334 - 359)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (363 - 387)

  • 0
  • 100
  • 200
  • 300
  • 402 a.a.
Protein Preferred Names Protein Names

zinc finger protein 558

ZNF558 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZNF558 Q96NG5 MAD2L2 Homo sapiens Q9UI95
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Endometrial Mixed Adenocarcinoma
Leber Plus Disease

  • Leber Congenital Amaurosis

  • Lca

  • Leber'S Amaurosis

  • Leber'S Disease

  • Amaurosis Congenita Of Leber

  • Amaurosis Congenita Of Leber, Type 1

  • Lhon Plus Disease

  • Congenital Absence Of The Rods And Cones

  • Congenital Retinal Blindness

  • Crb

  • Congenital Amaurosis Of Retinal Origin

  • Leber'S Congenital Amaurosis

  • Leber Congenital Amaurosis 1

  • Leber'S Congenital Tapetoretinal Degeneration

  • Leber'S Congenital Tapetoretinal Dysplasia

  • Lca1

  • Leber Congenital Amaurosis Type 1

  • Retinal Blindness, Congenital

  • Amaurosis, Leber Congenital

  • Dysgenesis Neuroepithelialis Retinae

  • Hereditary Epithelial Dysplasia Of Retina

  • Hereditary Retinal Aplasia

  • Heredoretinopathia Congenitalis

  • Leber Abiotrophy

  • Leber Congenital Tapetoretinal Degeneration

  • Lebers Congenital Amaurosis

  • Optic Atrophy, Hereditary, Leber
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16153 ZNF558 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ZNF558 MGD MGI:1921681
Rattus norvegicus ZNF558 RGD RGD:9264599
Others ZNF558 NCBI