Pim-1/2 kinase inhibitor 2
Pim-1/2 kinase inhibitor 2 (compound 5b) is a competitive PIM-1 and PIM-2 kinase inhibitor with IC50s of 1.31 μM and 0.67 μM, respectively. Pim-1/2 kinase inhibitor 2 shows in-vitro low cytotoxicity against normal human lung fibroblast Wi-38 cell line and potent in-vitro anticancer activity against myeloid leukaemia (NFS-60), liver (HepG-2), prostate (PC-3), and colon (Caco-2) cancer cell lines.
For research use only. We do not sell to patients.
- CAS No.: 2918764-16-4
- Formula: C25H19ClN4O3
- Molecular Weight:458.90
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
PIM1 1.31 μM (IC50) |
PIM2 0.67 μM (IC50) |
Chemical Information
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CAS No. 2918764-16-4
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Molecular Weight 458.90
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Formula C25H19ClN4O3
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SMILES
N#CC1=C(C2=CC3=CC(Cl)=CC=C3N=C2N4CCOCC4)C=C(C5=CC=CC(O)=C5)NC1=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pim-1/2 kinase inhibitor 2 Related Classifications
HY-157404 Related Classifications
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