1. JAK/STAT Signaling
  2. Pim
  3. GNE-955

GNE-955 

Cat. No.: HY-101783
Handling Instructions

GNE-955 is a potent and orally active pan Pim kinase inhibitor with Kis of 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively.

For research use only. We do not sell to patients.

GNE-955 Chemical Structure

GNE-955 Chemical Structure

CAS No. : 1527523-39-2

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Description

GNE-955 is a potent and orally active pan Pim kinase inhibitor with Kis of 0.018, 0.11, 0.08 nM for Pim1, Pim2, Pim3, respectively.

IC50 & Target[1]

PIM1

0.018 nM (Ki)

PIM2

0.11 nM (Ki)

PIM3

0.08 nM (Ki)

In Vitro

GNE-955 inhibits proliferation of MM.1S cells, with an IC50 value of 0.5 μM after 72 hours treatment[1].
GNE-955 (0.156-5 μM) inhibits the phosphorylation of BAD (s112), S6 (s235/236), S6 (s240/244) and 4EBP (s65), shows no effect on total BAD, S6 or 4EBP protein levels.[1]

Molecular Weight

416.48

Formula

C₂₂H₂₄N₈O

CAS No.

1527523-39-2

SMILES

CC1=CN=CC(C2=CC3=C(C=NN3C4=CC=C(OC)C(N5CCC[[email protected]](N)C5)=N4)C=N2)=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

GNE-955GNE955GNE 955PimPim kinasesInhibitorinhibitorinhibit

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