HDAC8/PIM1-IN-1
HDAC8/PIM1-IN-1 is a synthetic multi-target-directed ligand (MTDL) derived from 2-ureido-6-nitrobenzamide, and computational simulations predict it to be a dual-target inhibitor of HDAC8 and PIM1. HDAC8/PIM1-IN-1 holds potential for applications in research related to cancer and neurodegenerative diseases.
For research use only. We do not sell to patients.
- Formula: C20H18N6O4
- Molecular Weight:406.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
HDAC8 |
PIM1 |
In Vitro
HDAC8/PIM1-IN-1 (compound 7) (0.62-1.95 μM) is predicted as a preferential in silico multi-target hit compound, exhibiting balanced dual-target characteristics against HDAC8 and PIM1 kinase, with a calculated DTR of 0.92, HDAC8 ΔG of -7.789 kcal/mol, and PIM1 ΔG of -8.464 kcal/mol, indicating potential for balanced dual inhibition[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 406.39
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Formula C20H18N6O4
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SMILES
NC1=CC=CC=C1NC(C2=C(NC(NC3=CC=CC=C3N)=O)C=CC=C2[N+]([O-])=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HDAC8/PIM1-IN-1 Related Classifications
HY-189297 Related Classifications
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