2. Neuronal Signaling Protein Tyrosine Kinase/RTK JAK/STAT Signaling Cell Cycle/DNA Damage Stem Cell/Wnt Apoptosis
  3. Trk Receptor Anaplastic lymphoma kinase (ALK) c-Kit EGFR Pim Casein Kinase Checkpoint Kinase (Chk) CDK Apoptosis
  4. Multi-kinase-IN-6

Multi-kinase-IN-6 (compound 10e) is a multikinase inhibitor that shows good enzyme inhibitory activity against TrkA, ALK2, c-KIT, EGFR, PIM1, CK2α, CHK1, and CDK2. Multi-kinase-IN-6 reveals antiproliferative activity against MCF7, HCT116 and EKVX with IC50 values of 3.36 μM, 1.40 μM and 3.49 μM, respectively. Multi-kinase-IN-6 shows cell cycle arrest at the G1/S phase and G1 phase in MCF7 and HCT116 cells with good apoptotic effect.

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Multi-kinase-IN-6

Multi-kinase-IN-6 Chemical Structure

CAS No. : 3009081-73-3

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Multi-kinase-IN-6 Related Antibodies

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TrkA TrkB TrkC Trk

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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PIM1 PIM2 PIM3

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CK1 CK2

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Chk1 Chk2 BUBR1

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

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Description

Multi-kinase-IN-6 (compound 10e) is a multikinase inhibitor that shows good enzyme inhibitory activity against TrkA, ALK2, c-KIT, EGFR, PIM1, CK2α, CHK1, and CDK2. Multi-kinase-IN-6 reveals antiproliferative activity against MCF7, HCT116 and EKVX with IC50 values of 3.36 μM, 1.40 μM and 3.49 μM, respectively. Multi-kinase-IN-6 shows cell cycle arrest at the G1/S phase and G1 phase in MCF7 and HCT116 cells with good apoptotic effect[1].

IC50 & Target[1]

TrkA

0.33 μM (IC50)

CDK2

0.71 μM (IC50)

CK2

0.09 μM (IC50)

PIM1

0.42 μM (IC50)

Chk1

0.15 μM (IC50)

EGFR

0.1 μM (IC50)

c-KIT

0.05 μM (IC50)

ALK2

0.03 μM (IC50)

RET

0.53 μM (IC50)

FLT3

0.34 μM (IC50)

ROS1

0.75 μM (IC50)

Cellular Effect
Cell Line Type Value Description References
EKVX IC50
3.49 μM
Compound: 10e
Antiproliferative activity against human EKVX cells assessed as inhibition of cell viability by MTT assay
Antiproliferative activity against human EKVX cells assessed as inhibition of cell viability by MTT assay
[PMID: 37922829]
FHC IC50
32.405 μM
Compound: 10e
Cytotoxicity against human FHCs assessed as inhibition of cell viability by MTT assay
Cytotoxicity against human FHCs assessed as inhibition of cell viability by MTT assay
[PMID: 37922829]
HCT-116 IC50
1.4 μM
Compound: 10e
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell viability by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell viability by MTT assay
[PMID: 37922829]
MCF-10A IC50
28.745 μM
Compound: 10e
Cytotoxicity against human MCF-10A cells assessed as inhibition of cell viability by MTT assay
Cytotoxicity against human MCF-10A cells assessed as inhibition of cell viability by MTT assay
[PMID: 37922829]
MCF7 IC50
3.36 μM
Compound: 10e
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell viability by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell viability by MTT assay
[PMID: 37922829]
Molecular Weight

321.33

Formula

C17H15N5O2
CAS No.
SMILES

COC(C=C1)=CC=C1C2=CC=NC3=C(C4=NOC(C)=N4)C(C)=NN32
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Multi-kinase-IN-6 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Multi-kinase-IN-63009081-73-3Trk ReceptorAnaplastic lymphoma kinase (ALK)c-KitEGFRPimCasein KinaseCheckpoint Kinase (Chk)CDKApoptosisTropomyosin related kinase receptor Anaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246SCFRCD117Epidermal growth factor receptorErbB-1HER1Pim kinasesCyclin dependent kinaseTrkAALK2c-KITPIM1CK2αCHK1and CDK2Inhibitorinhibitorinhibit

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