Multi-kinase-IN-6
Multi-kinase-IN-6 (compound 10e) is a multikinase inhibitor that shows good enzyme inhibitory activity against TrkA, ALK2, c-KIT, EGFR, PIM1, CK2α, CHK1, and CDK2. Multi-kinase-IN-6 reveals antiproliferative activity against MCF7, HCT116 and EKVX with IC50 values of 3.36 μM, 1.40 μM and 3.49 μM, respectively. Multi-kinase-IN-6 shows cell cycle arrest at the G1/S phase and G1 phase in MCF7 and HCT116 cells with good apoptotic effect.
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- CAS No.: 3009081-73-3
- Formule: C17H15N5O2
- Masse moléculaire:321.33
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
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TrkA 0.33 μM (IC50) |
CDK2 0.71 μM (IC50) |
CK2 0.09 μM (IC50) |
PIM1 0.42 μM (IC50) |
Chk1 0.15 μM (IC50) |
EGFR 0.1 μM (IC50) |
c-KIT 0.05 μM (IC50) |
ALK2 0.03 μM (IC50) |
RET 0.53 μM (IC50) |
FLT3 0.34 μM (IC50) |
ROS1 0.75 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| EKVX | IC50 |
3.49 μM
Compound: 10e
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Antiproliferative activity against human EKVX cells assessed as inhibition of cell viability by MTT assay
Antiproliferative activity against human EKVX cells assessed as inhibition of cell viability by MTT assay
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[PMID: 37922829] |
| FHC | IC50 |
32.405 μM
Compound: 10e
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Cytotoxicity against human FHCs assessed as inhibition of cell viability by MTT assay
Cytotoxicity against human FHCs assessed as inhibition of cell viability by MTT assay
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[PMID: 37922829] |
| HCT-116 | IC50 |
1.4 μM
Compound: 10e
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Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell viability by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell viability by MTT assay
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[PMID: 37922829] |
| MCF-10A | IC50 |
28.745 μM
Compound: 10e
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Cytotoxicity against human MCF-10A cells assessed as inhibition of cell viability by MTT assay
Cytotoxicity against human MCF-10A cells assessed as inhibition of cell viability by MTT assay
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[PMID: 37922829] |
| MCF7 | IC50 |
3.36 μM
Compound: 10e
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Antiproliferative activity against human MCF7 cells assessed as inhibition of cell viability by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell viability by MTT assay
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[PMID: 37922829] |
Chemical Information
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CAS No. 3009081-73-3
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Masse moléculaire 321.33
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Formule C17H15N5O2
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SMILES
COC(C=C1)=CC=C1C2=CC=NC3=C(C4=NOC(C)=N4)C(C)=NN32
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Multi-kinase-IN-6 Related Classifications
HY-156470 Related Classifications
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