3009081-73-3
Chemical Structure
Multi-kinase-IN-6
- CAS No.: 3009081-73-3
- Formula:C17H15N5O2
- Molecular Weight:321.33
InChIKey: VDXGLZJPQRGNLY-UHFFFAOYSA-N
SMILES: COC(C=C1)=CC=C1C2=CC=NC3=C(C4=NOC(C)=N4)C(C)=NN32
Biological Activity: Multi-kinase-IN-6 (compound 10e) is a multikinase inhibitor that shows good enzyme inhibitory activity against TrkA, ALK2, c-KIT, EGFR, PIM1, CK2α, CHK1, and CDK2. Multi-kinase-IN-6 reveals antiproliferative activity against MCF7, HCT116 and EKVX with IC50 values of 3.36 μM, 1.40 μM and 3.49 μM, respectively. Multi-kinase-IN-6 shows cell cycle arrest at the G1/S phase and G1 phase in MCF7 and HCT116 cells with good apoptotic effect[1].
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Multi-kinase-IN-6 | Multi-kinase-IN-6 (compound 10e) is a multikinase inhibitor that shows good enzyme inhibitory activity against TrkA, ALK2, c-KIT, EGFR, PIM1, CK2α, CHK1, and CDK2. Multi-kinase-IN-6 reveals antiproliferative activity against MCF7, HCT116 and EKVX with IC50 values of 3.36 μM, 1.40 μM and 3.49 μM, respectively. Multi-kinase-IN-6 shows cell cycle arrest at the G1/S phase and G1 phase in MCF7 and HCT116 cells with good apoptotic effect. | |||||||||||||||||||||
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Keywords
