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Cat. No.: HY-178133

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Pim-1 kinase-IN-14

Pim-1 kinase-IN-14 is a PIM-1 kinase inhibitor with an IC₅₀ value of 94 nM. Pim-1 kinase-IN-14 shows broad-spectrum and high-efficiency anticancer activity against multiple human cancer cell lines, including liver cancer (HepG-2), colon cancer (Caco-2), myeloid leukemia (NFS-60), and prostate cancer (PC-3) cells. Pim-1 kinase-IN-14exerts its anticancer effects by inducing apoptosis and activating caspase 3/7. Pim-1 kinase-IN-14 can be used for the study of cancers associated with PIM-1 kinase overexpression.

For research use only. We do not sell to patients.

Formula: C₃₄H₂₅ClN₈O₅
Molecular Weight:661.07

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Pim-1 kinase-IN-14 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

PIM1

All Pim Isoforms :

All Caspase Isoforms :

In Vitro

Pim-1 kinase-IN-14 (Compound 6e) exhibits potent anticancer activity against HepG-2, Caco-2, NFS-60, and PC-3 cells^[1].
Pim-1 kinase-IN-14 induces apoptosis in HepG-2, Caco-2, PC-3, and NFS-60 cells^[1].
Pim-1 kinase-IN-14 significantly activates caspase 3/7 in HepG-2 cells^[1].
Pim-1 kinase-IN-14 shows potent inhibitory activity against PIM-1 kinase, with an IC₅₀ value of 0.094 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 661.07
Formula C₃₄H₂₅ClN₈O₅
SMILES

N#CC1=C(C2=CC3=CC(Cl)=CC=C3N=C2N4CCOCC4)C=C(C5=CC=CC(O)=C5)N=C1OCC6=CN(C7=CC=C([N+]([O-])=O)C=C7)N=N6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Abdelaziz ME, et al. Discovery of new pyridine-O-propargyl/1,2,3-triazole hybrids as competitive and non-competitive PIM-1 kinase inhibitors with apoptosis induction and caspase 3/7 activation capabilities. Bioorg Chem. 2025 Jul 15;162:108564. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Pim-1 kinase-IN-14

All Pim Isoforms

All Caspase Isoforms