AKR7A2 - aldo-keto reductase family 7 member A2 Gene

Homo sapiens

Also known as AFAR; AKR7; AFAR1; AFB1-AR1

Gene ID: 8574 | Gene type: protein coding

About AKR7A2

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:19,302,708-19,312,146 (from NCBI)

This gene has 5 transcripts (splice variants), 249 orthologues and 16 paralogues. Ubiquitous expression in kidney (RPKM 26.6), duodenum (RPKM 20.0) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication Enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

AKR7A2 Products(2)

mRNA	Protein	Name
NM_001320979.1	NP_001307908.1	aflatoxin B1 aldehyde reductase member 2 isoform 2
NM_003689.4	NP_003680.2	aflatoxin B1 aldehyde reductase member 2 isoform 1

AKR7A2 Protein Structure

Aldo_ket_red

0
100
200
300
359 a.a.

Protein Preferred Names

Protein Names

aflatoxin B1 aldehyde reductase member 2

AFB1 aldehyde reductase 1

Related Diseases

Diseases

Alias

Gamma-Amino Butyric Acid Metabolism Disorder

Disorder Of Gamma-Aminobutyric Acid Metabolism	Disorder Of Gaba Metabolism
Disorders Of Gaba - [Gamma Aminobutyric Acid] Metabolism

Succinic Semialdehyde Dehydrogenase Deficiency

4-Hydroxybutyric Aciduria	Ssadh Deficiency
Gamma-Hydroxybutyric Aciduria	Gaba Metabolic Defect
SSADHD	Ssadh
Succinate-Semialdehyde Dehydrogenase Deficiency	Gamma-Hydroxybutyricaciduria
4-Hydroxybutyricaciduria	Gamma-Hydroxybutyric Acidemia
Succinate Semialdehyde Dehydrogenase Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00540	AKR7A2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	AKR7A2	RGD	RGD:620311
Mus musculus	AKR7A2	MGD	MGI:107796

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