TNIP3 - TNFAIP3 interacting protein 3 Gene
Also Known as LIND; ABIN-3
Species: Homo sapiens
About TNIP3
This gene has 7 transcripts (splice variants), 116 orthologues and 2 paralogues. Biased expression in appendix (RPKM 1.2), lymph node (RPKM 0.4) and 11 other tissues.
Summary
Enables polyubiquitin modification-dependent protein binding activity. Involved in cellular response to lipopolysaccharide; negative regulation of I-kappaB kinase/NF-kappaB signaling; and Toll-like Receptor signaling pathway. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
TNIP3 Products (3)
| mRNA | Protein | Name |
|---|---|---|
| NM_001128843.2 | NP_001122315.2 | TNFAIP3-interacting protein 3 isoform 2 |
| NM_001244764.2 | NP_001231693.1 | TNFAIP3-interacting protein 3 isoform 3 |
| NM_024873.6 | NP_079149.3 | TNFAIP3-interacting protein 3 isoform 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables polyubiquitin modification-dependent protein binding |
IDA
IDA: Inferred from direct assay
|
18212736 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
25416956 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in MyD88-independent toll-like receptor signaling pathway |
IDA
IDA: Inferred from direct assay
|
17088249 | GOA |
| involved in cellular response to lipopolysaccharide |
IDA
IDA: Inferred from direct assay
|
17088249 | GOA |
| involved in negative regulation of canonical NF-kappaB signal transduction |
IDA
IDA: Inferred from direct assay
|
17088249 | GOA |
| involved in toll-like receptor 4 signaling pathway |
IDA
IDA: Inferred from direct assay
|
17088249 | GOA |
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
TNFAIP3-interacting protein 3 |
|
TNIP3 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
TNIP3 | Q96KP6 | NF2 | Homo sapiens | P35240 | 32814053 | |
|
Intra
|
TNIP3 | Q96KP6 | NF2 | Homo sapiens | P35240 | 32814053 | |
|
Intra
|
TNIP3 | Q96KP6 | NF2 | Homo sapiens | P35240 | 32814053 | |
|
Intra
|
TNIP3 | Q96KP6 | KRT40 | Homo sapiens | Q6A162 | 25416956 | |
|
Intra
|
TNIP3 | Q96KP6 | KRT40 | Homo sapiens | Q6A162 | 25416956 | |
|
Intra
|
TNIP3 | Q96KP6 | DMWD | Homo sapiens | G5E9A7 | 32814053 | |
|
Intra
|
TNIP3 | Q96KP6 | DMWD | Homo sapiens | G5E9A7 | 32814053 | |
|
Intra
|
TNIP3 | Q96KP6 | DMWD | Homo sapiens | G5E9A7 | 32814053 | |
|
Intra
|
TNIP3 | Q96KP6 | MTUS2 | Homo sapiens | Q5JR59-3 | 32296183 | |
|
Intra
|
TNIP3 | Q96KP6 | MTUS2 | Homo sapiens | Q5JR59-3 | 32296183 | |
|
Intra
|
TNIP3 | Q96KP6 | ATN1 | Homo sapiens | Q86V38 | 32814053 | |
|
Intra
|
TNIP3 | Q96KP6 | ATN1 | Homo sapiens | Q86V38 | 32814053 | |
|
Intra
|
TNIP3 | Q96KP6 | ATN1 | Homo sapiens | Q86V38 | 32814053 | |
|
Intra
|
TNIP3 | Q96KP6 | PIBF1 | Homo sapiens | Q4G0R1 | 32296183 | |
|
Intra
|
TNIP3 | Q96KP6 | PIBF1 | Homo sapiens | Q4G0R1 | 32296183 | |
|
Intra
|
TNIP3 | Q96KP6 | NOTCH2NLC | Homo sapiens | P0DPK4 | 32296183 | |
|
Intra
|
TNIP3 | Q96KP6 | NOTCH2NLC | Homo sapiens | P0DPK4 | 32296183 | |
|
Intra
|
TNIP3 | Q96KP6 | TRIM8 | Homo sapiens | Q9BZR9 | 32296183 | |
|
Intra
|
TNIP3 | Q96KP6 | TRIM8 | Homo sapiens | Q9BZR9 | 32296183 | |
|
Intra
|
TNIP3 | Q96KP6 | TRIM8 | Homo sapiens | Q9BZR9 | 32296183 | |
|
Intra
|
TNIP3 | Q96KP6 | TNIP1 | Homo sapiens | Q15025 | 25416956 | |
|
Intra
|
TNIP3 | Q96KP6 | TNIP1 | Homo sapiens | Q15025 | 32296183 | |
|
Intra
|
TNIP3 | Q96KP6 | TNIP1 | Homo sapiens | Q15025 | 25416956 | |
|
Intra
|
TNIP3 | Q96KP6 | TNIP1 | Homo sapiens | Q15025 | 32296183 | |
|
Intra
|
TNIP3 | Q96KP6 | KPNA3 | Homo sapiens | O00505 | 32296183 | |
|
Intra
|
TNIP3 | Q96KP6 | KPNA3 | Homo sapiens | O00505 | 32296183 | |
|
Intra
|
TNIP3 | Q96KP6 | CYSRT1 | Homo sapiens | A8MQ03 | 32296183 | |
|
Intra
|
TNIP3 | Q96KP6 | CYSRT1 | Homo sapiens | A8MQ03 | 32296183 | |
|
Intra
|
TNIP3 | Q96KP6 | CCN3 | Homo sapiens | P48745 | 32296183 | |
|
Intra
|
TNIP3 | Q96KP6 | CCN3 | Homo sapiens | P48745 | 32296183 | |
|
Intra
|
TNIP3 | Q96KP6 | PMP22 | Homo sapiens | A0A6Q8PF08 | 32814053 | |
|
Intra
|
TNIP3 | Q96KP6 | PMP22 | Homo sapiens | A0A6Q8PF08 | 32814053 | |
|
Intra
|
TNIP3 | Q96KP6 | PMP22 | Homo sapiens | A0A6Q8PF08 | 32814053 | |
|
Intra
|
TNIP3 | Q96KP6 | SPRED1 | Homo sapiens | Q7Z699 | 32814053 | |
|
Intra
|
TNIP3 | Q96KP6 | SPRED1 | Homo sapiens | Q7Z699 | 32814053 | |
|
Intra
|
TNIP3 | Q96KP6 | SPRED1 | Homo sapiens | Q7Z699 | 32814053 | |
|
Intra
|
TNIP3 | Q96KP6 | TNFAIP3 | Homo sapiens | P21580 | 25416956 | |
|
Intra
|
TNIP3 | Q96KP6 | TNFAIP3 | Homo sapiens | P21580 | 25416956 | |
|
Intra
|
TNIP3 | Q96KP6 | TNFAIP3 | Homo sapiens | P21580 | 25416956 | |
|
Intra
|
TNIP3 | Q96KP6 | TAX1BP1 | Homo sapiens | Q86VP1 | 32296183 | |
|
Intra
|
TNIP3 | Q96KP6 | TAX1BP1 | Homo sapiens | Q86VP1 | 25416956 | |
|
Intra
|
TNIP3 | Q96KP6 | TAX1BP1 | Homo sapiens | Q86VP1 | 32296183 | |
|
Intra
|
TNIP3 | Q96KP6 | TAX1BP1 | Homo sapiens | Q86VP1 | 25416956 | |
|
Intra
|
TNIP3 | Q96KP6 | MAGEA2 | Homo sapiens | P43356 | 32296183 | |
|
Intra
|
TNIP3 | Q96KP6 | MAGEA2 | Homo sapiens | P43356 | 32296183 | |
|
Intra
|
TNIP3 | Q96KP6 | FAM161A | Homo sapiens | Q3B820 | 32296183 | |
|
Intra
|
TNIP3 | Q96KP6 | FAM161A | Homo sapiens | Q3B820 | 32296183 | |
|
Intra
|
TNIP3 | Q96KP6 | DAZAP2 | Homo sapiens | Q15038 | 25416956 | |
|
Intra
|
TNIP3 | Q96KP6 | DAZAP2 | Homo sapiens | Q15038 | 32296183 | |
|
Intra
|
TNIP3 | Q96KP6 | DAZAP2 | Homo sapiens | Q15038 | 25416956 | |
|
Intra
|
TNIP3 | Q96KP6 | DAZAP2 | Homo sapiens | Q15038 | 32296183 | |
|
Intra
|
TNIP3 | Q96KP6 | LITAF | Homo sapiens | Q99732 | 32296183 | |
|
Intra
|
TNIP3 | Q96KP6 | LZTS2 | Homo sapiens | Q9BRK4 | 32296183 | |
|
Intra
|
TNIP3 | Q96KP6 | LZTS2 | Homo sapiens | Q9BRK4 | 32296183 | |
|
Intra
|
TNIP3 | Q96KP6 | LZTS2 | Homo sapiens | Q9BRK4 | 32296183 | |
|
Intra
|
TNIP3 | Q96KP6 | ZBTB8A | Homo sapiens | Q96BR9 | 25416956 | |
|
Intra
|
TNIP3 | Q96KP6 | ZBTB8A | Homo sapiens | Q96BR9 | 25416956 | |
|
Intra
|
TNIP3 | Q96KP6 | PLSCR3 | Homo sapiens | Q9NRY6 | 32296183 | |
|
Intra
|
TNIP3 | Q96KP6 | PLSCR3 | Homo sapiens | Q9NRY6 | 32296183 | |
|
Intra
|
TNIP3 | Q96KP6 | PLSCR3 | Homo sapiens | Q9NRY6 | 32296183 | |
|
Intra
|
TNIP3 | Q96KP6 | NOTCH2NLA | Homo sapiens | Q7Z3S9 | 25416956 |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Noonan Syndrome 1 |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | TNIP3 | RGD | RGD:1588732 |
| Macaca mulatta | TNIP3 | VGNC | VGNC:79193 |
| Canis familiaris | TNIP3 | VGNC | VGNC:47678 |
| Mus musculus | TNIP3 | MGD | MGI:3041165 |
| Felis catus | TNIP3 | VGNC | VGNC:66418 |
| Bos taurus | TNIP3 | VGNC | VGNC:36181 |
| Others | TNIP3 | NCBI |