TNIP3 - TNFAIP3 interacting protein 3 Gene

Also Known as LIND; ABIN-3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79931

About TNIP3

Cytogenetic location: 4q27 Genomic coordinates (GRCh38): 4:121,131,408-121,227,483 (from NCBI)

This gene has 7 transcripts (splice variants), 116 orthologues and 2 paralogues. Biased expression in appendix (RPKM 1.2), lymph node (RPKM 0.4) and 11 other tissues.

Summary

Enables polyubiquitin modification-dependent protein binding activity. Involved in cellular response to lipopolysaccharide; negative regulation of I-kappaB kinase/NF-kappaB signaling; and Toll-like Receptor signaling pathway. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

TNIP3 Products (3)

mRNA Protein Name
NM_001128843.2 NP_001122315.2 TNFAIP3-interacting protein 3 isoform 2
NM_001244764.2 NP_001231693.1 TNFAIP3-interacting protein 3 isoform 3
NM_024873.6 NP_079149.3 TNFAIP3-interacting protein 3 isoform 1
Molecular Function GO Annotation Evidence References Source
enables polyubiquitin modification-dependent protein binding IDA
IDA: Inferred from direct assay
18212736 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in MyD88-independent toll-like receptor signaling pathway IDA
IDA: Inferred from direct assay
17088249 GOA
involved in cellular response to lipopolysaccharide IDA
IDA: Inferred from direct assay
17088249 GOA
involved in negative regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
17088249 GOA
involved in toll-like receptor 4 signaling pathway IDA
IDA: Inferred from direct assay
17088249 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

TNFAIP3-interacting protein 3

  • A20-binding inhibitor of NF-kappa-B activation 3

TNIP3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TNIP3 Q96KP6 NF2 Homo sapiens P35240 32814053
Intra
TNIP3 Q96KP6 NF2 Homo sapiens P35240 32814053
Intra
TNIP3 Q96KP6 NF2 Homo sapiens P35240 32814053
Intra
TNIP3 Q96KP6 KRT40 Homo sapiens Q6A162 25416956
Intra
TNIP3 Q96KP6 KRT40 Homo sapiens Q6A162 25416956
Intra
TNIP3 Q96KP6 DMWD Homo sapiens G5E9A7 32814053
Intra
TNIP3 Q96KP6 DMWD Homo sapiens G5E9A7 32814053
Intra
TNIP3 Q96KP6 DMWD Homo sapiens G5E9A7 32814053
Intra
TNIP3 Q96KP6 MTUS2 Homo sapiens Q5JR59-3 32296183
Intra
TNIP3 Q96KP6 MTUS2 Homo sapiens Q5JR59-3 32296183
Intra
TNIP3 Q96KP6 ATN1 Homo sapiens Q86V38 32814053
Intra
TNIP3 Q96KP6 ATN1 Homo sapiens Q86V38 32814053
Intra
TNIP3 Q96KP6 ATN1 Homo sapiens Q86V38 32814053
Intra
TNIP3 Q96KP6 PIBF1 Homo sapiens Q4G0R1 32296183
Intra
TNIP3 Q96KP6 PIBF1 Homo sapiens Q4G0R1 32296183
Intra
TNIP3 Q96KP6 NOTCH2NLC Homo sapiens P0DPK4 32296183
Intra
TNIP3 Q96KP6 NOTCH2NLC Homo sapiens P0DPK4 32296183
Intra
TNIP3 Q96KP6 TRIM8 Homo sapiens Q9BZR9 32296183
Intra
TNIP3 Q96KP6 TRIM8 Homo sapiens Q9BZR9 32296183
Intra
TNIP3 Q96KP6 TRIM8 Homo sapiens Q9BZR9 32296183
Intra
TNIP3 Q96KP6 TNIP1 Homo sapiens Q15025 25416956
Intra
TNIP3 Q96KP6 TNIP1 Homo sapiens Q15025 32296183
Intra
TNIP3 Q96KP6 TNIP1 Homo sapiens Q15025 25416956
Intra
TNIP3 Q96KP6 TNIP1 Homo sapiens Q15025 32296183
Intra
TNIP3 Q96KP6 KPNA3 Homo sapiens O00505 32296183
Intra
TNIP3 Q96KP6 KPNA3 Homo sapiens O00505 32296183
Intra
TNIP3 Q96KP6 CYSRT1 Homo sapiens A8MQ03 32296183
Intra
TNIP3 Q96KP6 CYSRT1 Homo sapiens A8MQ03 32296183
Intra
TNIP3 Q96KP6 CCN3 Homo sapiens P48745 32296183
Intra
TNIP3 Q96KP6 CCN3 Homo sapiens P48745 32296183
Intra
TNIP3 Q96KP6 PMP22 Homo sapiens A0A6Q8PF08 32814053
Intra
TNIP3 Q96KP6 PMP22 Homo sapiens A0A6Q8PF08 32814053
Intra
TNIP3 Q96KP6 PMP22 Homo sapiens A0A6Q8PF08 32814053
Intra
TNIP3 Q96KP6 SPRED1 Homo sapiens Q7Z699 32814053
Intra
TNIP3 Q96KP6 SPRED1 Homo sapiens Q7Z699 32814053
Intra
TNIP3 Q96KP6 SPRED1 Homo sapiens Q7Z699 32814053
Intra
TNIP3 Q96KP6 TNFAIP3 Homo sapiens P21580 25416956
Intra
TNIP3 Q96KP6 TNFAIP3 Homo sapiens P21580 25416956
Intra
TNIP3 Q96KP6 TNFAIP3 Homo sapiens P21580 25416956
Intra
TNIP3 Q96KP6 TAX1BP1 Homo sapiens Q86VP1 32296183
Intra
TNIP3 Q96KP6 TAX1BP1 Homo sapiens Q86VP1 25416956
Intra
TNIP3 Q96KP6 TAX1BP1 Homo sapiens Q86VP1 32296183
Intra
TNIP3 Q96KP6 TAX1BP1 Homo sapiens Q86VP1 25416956
Intra
TNIP3 Q96KP6 MAGEA2 Homo sapiens P43356 32296183
Intra
TNIP3 Q96KP6 MAGEA2 Homo sapiens P43356 32296183
Intra
TNIP3 Q96KP6 FAM161A Homo sapiens Q3B820 32296183
Intra
TNIP3 Q96KP6 FAM161A Homo sapiens Q3B820 32296183
Intra
TNIP3 Q96KP6 DAZAP2 Homo sapiens Q15038 25416956
Intra
TNIP3 Q96KP6 DAZAP2 Homo sapiens Q15038 32296183
Intra
TNIP3 Q96KP6 DAZAP2 Homo sapiens Q15038 25416956
Intra
TNIP3 Q96KP6 DAZAP2 Homo sapiens Q15038 32296183
Intra
TNIP3 Q96KP6 LITAF Homo sapiens Q99732 32296183
Intra
TNIP3 Q96KP6 LZTS2 Homo sapiens Q9BRK4 32296183
Intra
TNIP3 Q96KP6 LZTS2 Homo sapiens Q9BRK4 32296183
Intra
TNIP3 Q96KP6 LZTS2 Homo sapiens Q9BRK4 32296183
Intra
TNIP3 Q96KP6 ZBTB8A Homo sapiens Q96BR9 25416956
Intra
TNIP3 Q96KP6 ZBTB8A Homo sapiens Q96BR9 25416956
Intra
TNIP3 Q96KP6 PLSCR3 Homo sapiens Q9NRY6 32296183
Intra
TNIP3 Q96KP6 PLSCR3 Homo sapiens Q9NRY6 32296183
Intra
TNIP3 Q96KP6 PLSCR3 Homo sapiens Q9NRY6 32296183
Intra
TNIP3 Q96KP6 NOTCH2NLA Homo sapiens Q7Z3S9 25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Noonan Syndrome 1
  • Noonan Syndrome

  • NS1

  • Male Turner Syndrome

  • Female Pseudo-Turner Syndrome

  • Turner Phenotype With Normal Karyotype

  • Noonan Syndrome With Pigmented Villonodular Synovitis

  • Turner'S Phenotype, Karyotype Normal

  • Familial Turner Syndrome

  • Noonan'S Syndrome

  • Noonan-Ehmke Syndrome

  • Ns

  • Pseudo-Ullrich-Turner Syndrome

  • Turner Syndrome In Female With X Chromosome

  • Turner-Like Syndrome

  • Ullrich-Noonan Syndrome

  • Noonan-Like/Multiple Giant Cell Lesion Syndrome

  • Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

  • Pterygium Colli Syndrome

  • Noonan Syndrome, Type 1

  • Turner Syndrome, Male

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TNIP3 RGD RGD:1588732
Macaca mulatta TNIP3 VGNC VGNC:79193
Canis familiaris TNIP3 VGNC VGNC:47678
Mus musculus TNIP3 MGD MGI:3041165
Felis catus TNIP3 VGNC VGNC:66418
Bos taurus TNIP3 VGNC VGNC:36181
Others TNIP3 NCBI