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PLSCR3 - phospholipid scramblase 3 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57048

About PLSCR3

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,389,727-7,394,525 (from NCBI)

This gene has 13 transcripts (splice variants), 1 gene allele, 407 orthologues and 4 paralogues. Ubiquitous expression in spleen (RPKM 12.9), fat (RPKM 12.1) and 25 other tissues.

Summary

Enables several functions, including calcium-dependent protein binding activity; metal ion binding activity; and phospholipid scramblase activity. Involved in several processes, including cardiolipin biosynthetic process; regulation of apoptotic process; and regulation of release of cytochrome c from mitochondria. Located in cytosol; mitochondrion; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

PLSCR3 Products (6)

mRNA	Protein	Name
NM_001201576.2	NP_001188505.1	phospholipid scramblase 3 isoform 1
NM_001369407.1	NP_001356336.1	phospholipid scramblase 3 isoform 1
NM_001369420.1	NP_001356349.1	phospholipid scramblase 3 isoform 2
NM_001369421.1	NP_001356350.1	phospholipid scramblase 3 isoform 3
NM_001369422.1	NP_001356351.1	phospholipid scramblase 3 isoform 3
NM_020360.4	NP_065093.2	phospholipid scramblase 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium ion binding	IMP IMP: Inferred from mutant phenotype	18358005	GOA
enables calcium-dependent protein binding	IPI IPI: Inferred from physical interaction	18256029	GOA
enables lead ion binding	IMP IMP: Inferred from mutant phenotype	31769662	GOA
enables magnesium ion binding	IMP IMP: Inferred from mutant phenotype	29337693	GOA
enables mercury ion binding	IMP IMP: Inferred from mutant phenotype	31769662	GOA
enables phospholipid scramblase activity	IMP IMP: Inferred from mutant phenotype	14573790	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12649167	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	12649167	GOA
involved in cardiolipin biosynthetic process	IMP IMP: Inferred from mutant phenotype	16939411	GOA
involved in regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	14573790	GOA
involved in regulation of release of cytochrome c from mitochondria	IMP IMP: Inferred from mutant phenotype	14573790	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	12649167	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	12649167	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19333378	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLSCR3 Protein Structure

Scramblase

0
100
200
295 a.a.

Protein Preferred Names	Protein Names
phospholipid scramblase 3	PL scramblase 3

PLSCR3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PLSCR3	Q9NRY6	KRTAP19-7	Homo sapiens	Q3SYF9	Y2H Prey Pooling	32296183
Intra	PLSCR3	Q9NRY6	KRTAP19-7	Homo sapiens	Q3SYF9	Y2H Array	32296183
Intra	PLSCR3	Q9NRY6	LCE4A	Homo sapiens	Q5TA78	Y2H Prey Pooling	32296183
Intra	PLSCR3	Q9NRY6	LCE4A	Homo sapiens	Q5TA78	Y2H Array	32296183
Intra	PLSCR3	Q9NRY6	KRTAP11-1	Homo sapiens	Q8IUC1	Y2H Array	32296183
Intra	PLSCR3	Q9NRY6	KRTAP11-1	Homo sapiens	Q8IUC1	Y2H Prey Pooling	32296183
Intra	PLSCR3	Q9NRY6	LCE2B	Homo sapiens	O14633	Y2H Array	32296183
Intra	PLSCR3	Q9NRY6	LCE2B	Homo sapiens	O14633	Y2H Prey Pooling	32296183
Intra	PLSCR3	Q9NRY6	LCE5A	Homo sapiens	Q5TCM9	Y2H Array	32296183
Intra	PLSCR3	Q9NRY6	LCE5A	Homo sapiens	Q5TCM9	Y2H Prey Pooling	32296183
Intra	PLSCR3	Q9NRY6	ACTMAP	Homo sapiens	Q5BKX5-3	Y2H Prey Pooling	32296183
Intra	PLSCR3	Q9NRY6	ACTMAP	Homo sapiens	Q5BKX5-3	Y2H Array	32296183
Intra	PLSCR3	Q9NRY6	KRTAP15-1	Homo sapiens	Q3LI76	Y2H Prey Pooling	32296183
Intra	PLSCR3	Q9NRY6	KRTAP15-1	Homo sapiens	Q3LI76	Y2H Array	32296183
Intra	PLSCR3	Q9NRY6	S100A7L2	Homo sapiens	Q5SY68	Y2H Prey Pooling	32296183
Intra	PLSCR3	Q9NRY6	S100A7L2	Homo sapiens	Q5SY68	Y2H Array	32296183
Intra	PLSCR3	Q9NRY6	WWOX	Homo sapiens	Q9NZC7-5	Validated Y2H	32296183
Intra	PLSCR3	Q9NRY6	WWOX	Homo sapiens	Q9NZC7-5	Y2H Prey Pooling	32296183
Intra	PLSCR3	Q9NRY6	WWOX	Homo sapiens	Q9NZC7-5	Y2H Array	32296183
Intra	PLSCR3	Q9NRY6	KRTAP6-1	Homo sapiens	Q3LI64	Y2H Array	32296183
Intra	PLSCR3	Q9NRY6	KRTAP6-1	Homo sapiens	Q3LI64	Y2H Prey Pooling	32296183
Intra	PLSCR3	Q9NRY6	LCE1C	Homo sapiens	Q5T751	Y2H Prey Pooling	32296183
Intra	PLSCR3	Q9NRY6	LCE1C	Homo sapiens	Q5T751	Y2H Array	32296183
Intra	PLSCR3	Q9NRY6	KRTAP19-6	Homo sapiens	Q3LI70	Y2H Prey Pooling	32296183
Intra	PLSCR3	Q9NRY6	KRTAP19-6	Homo sapiens	Q3LI70	Y2H Array	32296183
Intra	PLSCR3	Q9NRY6	C10orf55	Homo sapiens	Q5SWW7	Y2H Array	32296183
Intra	PLSCR3	Q9NRY6	C10orf55	Homo sapiens	Q5SWW7	Y2H Prey Pooling	32296183
Intra	PLSCR3	Q9NRY6	TRIP13	Homo sapiens	Q15645	Y2H Prey Pooling	25416956
Intra	PLSCR3	Q9NRY6	TRIP13	Homo sapiens	Q15645	Y2H Prey Pooling	32296183
Intra	PLSCR3	Q9NRY6	TRIP13	Homo sapiens	Q15645	Y2H Array	32296183
Intra	PLSCR3	Q9NRY6	KRTAP3-3	Homo sapiens	Q9BYR6	Y2H Prey Pooling	32296183
Intra	PLSCR3	Q9NRY6	KRTAP3-3	Homo sapiens	Q9BYR6	Y2H Array	32296183
Intra	PLSCR3	Q9NRY6	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	PLSCR3	Q9NRY6	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	PLSCR3	Q9NRY6	AIPL1	Homo sapiens	Q9NZN9	Validated Y2H	32296183
Intra	PLSCR3	Q9NRY6	C22orf39	Homo sapiens	Q6P5X5	Y2H Array	32296183
Intra	PLSCR3	Q9NRY6	C22orf39	Homo sapiens	Q6P5X5	Y2H Prey Pooling	32296183
Intra	PLSCR3	Q9NRY6	HOXA1	Homo sapiens	P49639	Y2H Array	32296183
Intra	PLSCR3	Q9NRY6	HOXA1	Homo sapiens	P49639	Y2H Prey Pooling	32296183
Intra	PLSCR3	Q9NRY6	CATSPER1	Homo sapiens	Q8NEC5	Validated Y2H	25416956
Intra	PLSCR3	Q9NRY6	CATSPER1	Homo sapiens	Q8NEC5	Y2H Array	25416956
Intra	PLSCR3	Q9NRY6	CATSPER1	Homo sapiens	Q8NEC5	Y2H Prey Pooling	25416956
Intra	PLSCR3	Q9NRY6	STK16	Homo sapiens	O75716	Y2H Array	25416956
Intra	PLSCR3	Q9NRY6	SMCP	Homo sapiens	P49901	Y2H Prey Pooling	32296183
Intra	PLSCR3	Q9NRY6	SMCP	Homo sapiens	P49901	Y2H Array	32296183
Intra	PLSCR3	Q9NRY6	KRTAP3-2	Homo sapiens	Q9BYR7	Y2H Array	32296183
Intra	PLSCR3	Q9NRY6	KRTAP3-2	Homo sapiens	Q9BYR7	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

PLSCR3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81927	PLSCR3 Antibody (YA1672)	WB	Human, Mouse, Rat
HY-P81927A	PLSCR3 Antibody (YA1672)(PBS only)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Barth Syndrome	3-Methylglutaconic Aciduria Type 2 BTHS Cardioskeletal Myopathy With Neutropenia And Abnormal Mitochondria Mga Type Ii Mga2 Mgca2 Mga Type 2 3-Methylglutaconic Aciduria Type Ii 3-Methylglutaconic Aciduria, Type Ii Mga, Type Ii 3-Methylglutaconicaciduria Type 2 3-Methylglutaconicaciduria Type Ii Taz Defect 3 Methylglutaconic Aciduria, Type Ii Dnajc19 Defect Cardioskeletal Myopathy-Neutropenia Syndrome X-Linked Cardioskeletal Myopathy And Neutropenia 3-Alpha-Methylglutaconic Aciduria Type 2 Agm2 Cardioskeletal Myopathy-Neutropenia Invm Left Ventricular Non-Compaction Isolated X-Linked Non-Compaction Of Left Ventricular Myocardium Isolated X-Linked Agammaglobulinemia 2, Autosomal Recessive

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10742	PLSCR3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PLSCR3	MGD	MGI:1917560
Felis catus	PLSCR3	VGNC	VGNC:64247
Bos taurus	PLSCR3	VGNC	VGNC:55863
Rattus norvegicus	PLSCR3	RGD	RGD:1307016
Macaca mulatta	PLSCR3	VGNC	VGNC:76035
Canis familiaris	PLSCR3	VGNC	VGNC:56014
Others	PLSCR3	NCBI