PLSCR3 Antibody (YA1672)
(Synonyms: Phospholipid scramblase 3; PL scramblase 3)PLSCR3 Antibody (YA1672) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PLSCR3.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
PLSCR3 Antibody (YA1672) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PLSCR3.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 32 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 32 kDa
Entrez Gene: 57048 Human ; 70310 Mouse ; 360549 Rat
SwissProt: Q9NRY6 Human ; Q9JIZ9 Mouse ; Q6QBQ4 Rat
OMIM: 607611 Human
A synthetic peptide of human PLSCR3
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PLSCR3 catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of the phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer membrane of the mitochondria. Plays an important role in mitochondrial respiratory function, morphology, and apoptotic response. Mediates the translocation of cardiolipin from the mitochondrial inner membrane to outer membrane enhancing t-Bid induced cytochrome c release and apoptosis. Enhances TNFSF10-induced apoptosis by regulating the distribution of cardiolipin in the mitochondrial membrane resulting in increased release of apoptogenic factors and consequent amplification of the activity of caspases. Regulates cardiolipin de novo biosynthesis and its resynthesis[1][2][3][4][5][6][7][8].
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Subcellular Localization
Mitochondrion membrane; Single-pass type II membrane protein; Mitochondrion inner membrane; Single-pass type II membrane protein; Nucleus
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Expression
Tissue_specificity:Expressed in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine and peripheral blood lymphocytes. Not detected in testis, brain and liver -
Subunit
Monomer (PubMed:29337693). Forms homooligomers upon binding to Ca(2+), Pb(2+) and Hg(2+) ions (PubMed:29337693, PubMed:31769662). Interacts with PDCD6 in a calcium-dependent manner (PubMed:18256029). Interacts with PRKCD; interaction is enhanced by UV irradiation (PubMed:12649167)
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SwissProt ID
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Synonyms
Phospholipid scramblase 3; PL scramblase 3
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Research Field
Cardiovascular
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